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dc.contributor.authorSushentsev, Nikita
dc.contributor.authorKaggie, Joshua D.
dc.contributor.authorBuonincontri, Guido
dc.contributor.authorSchulte, Rolf F.
dc.contributor.authorGraves, Martin J.
dc.contributor.authorGnanapragasam, Vincent J.
dc.contributor.authorBarrett, Tristan
dc.date.accessioned2020-11-24T16:21:06Z
dc.date.available2020-11-24T16:21:06Z
dc.date.issued2020-11-24
dc.date.submitted2020-07-13
dc.identifier.others41598-020-77331-4
dc.identifier.other77331
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/313258
dc.description.abstractAbstract: Magnetic resonance fingerprinting (MRF) is a rapidly developing fast quantitative mapping technique able to produce multiple property maps with reduced sensitivity to motion. MRF has shown promise in improving the diagnosis of clinically significant prostate cancer but requires further validation as part of a prostate multiparametric (mp) MRI protocol. mpMRI protocol mandates the inclusion of dynamic contrast enhanced (DCE) imaging, known for its significant T1 shortening effect. MRF could be used to measure both pre- and post-contrast T1 values, but its utility must be assessed. In this proof-of-concept study, we sought to evaluate the variation in MRF T1 measurements post gadolinium-based contrast agent (GBCA) injection and the utility of such T1 measurements to differentiate peripheral and transition zone tumours from normal prostatic tissue. We found that the T1 variation in all tissues increased considerably post-GBCA following the expected significant T1 shortening effect, compromising the ability of MRF T1 to identify transition zone lesions. We, therefore, recommend performing MRF T1 prior to DCE imaging to maintain its benefit for improving detection of both peripheral and transition zone lesions while reducing additional scanning time. Demonstrating the effect of GBCA on MRF T1 relaxometry in patients also paves the way for future clinical studies investigating the added value of post-GBCA MRF in PCa, including its dynamic analysis as in DCE-MRF.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/67
dc.subject/692/4025
dc.subject/692/308
dc.subject/692/4028
dc.subject/692/4028/67/2321
dc.subject/692/4028/67/589
dc.subjectarticle
dc.titleThe effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T 1 relaxometry in patients with prostate cancer
dc.typeArticle
dc.date.updated2020-11-24T16:21:04Z
prism.issueIdentifier1
prism.publicationNameScientific Reports
prism.volume10
dc.identifier.doi10.17863/CAM.60363
dcterms.dateAccepted2020-11-03
rioxxterms.versionofrecord10.1038/s41598-020-77331-4
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2045-2322


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)