Show simple item record

dc.contributor.authorLorgen-Ritchie, Marlene
dc.contributor.authorMurray, Alison D.
dc.contributor.authorStaff, Roger
dc.contributor.authorFerguson-Smith, Anne C.
dc.contributor.authorRichards, Marcus
dc.contributor.authorHorgan, Graham W.
dc.contributor.authorPhillips, Louise H.
dc.contributor.authorHoad, Gwen
dc.contributor.authorMcNeil, Chris
dc.contributor.authorRibeiro, Antonio
dc.contributor.authorHaggarty, Paul
dc.date.accessioned2021-01-13T17:22:07Z
dc.date.available2021-01-13T17:22:07Z
dc.date.issued2021-01-13
dc.date.submitted2020-06-22
dc.identifier.others41598-020-78062-2
dc.identifier.other78062
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316141
dc.descriptionFunder: Rural and Environment Science and Analytical Services Division; doi: http://dx.doi.org/10.13039/100011310
dc.description.abstractAbstract: Epigenetic imprinting is important for neurogenesis and brain function. Hippocampal volumes and brain hyperintensities in late life have been associated with early life circumstances. Epigenetic imprinting may underpin these associations. Methylation was measured at 982 sites in 13 imprinted locations in blood samples from a longitudinal cohort by bisulphite amplicon sequencing. Hippocampal volumes and hyperintensities were determined at age 64y and 72y using MRI. Hyperintensities were determined in white matter, grey matter and infratentorial regions. Permutation methods were used to adjust for multiple testing. At 64y, H19/IGF2 and NESPAS methylation predicted hippocampal volumes. PEG3 predicted hyperintensities in hippocampal grey matter, and white matter. GNASXL predicted grey matter hyperintensities. Changes with age were predicted for hippocampal volume (MEST1, KvDMR, L3MBTL, GNASXL), white matter (MEST1, PEG3) and hippocampal grey matter hyperintensities (MCTS2, GNASXL, NESPAS, L3MBTL, MCTS2, SNRPN, MEST1). Including childhood cognitive ability, years in education, or socioeconomic status as additional explanatory variables in regression analyses did not change the overall findings. Imprinting methylation in multiple genes predicts brain structures, and their change over time. These findings are potentially relevant to the development of novel tests of brain structure and function across the life-course, strategies to improve cognitive outcomes, and our understanding of early influences on brain development and function.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/208/176/1968
dc.subject/631/337/176/1988
dc.subject/631/378/2612
dc.subjectarticle
dc.titleImprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life
dc.typeArticle
dc.date.updated2021-01-13T17:22:07Z
prism.issueIdentifier1
prism.publicationNameScientific Reports
prism.volume11
dc.identifier.doi10.17863/CAM.63249
dcterms.dateAccepted2020-10-16
rioxxterms.versionofrecord10.1038/s41598-020-78062-2
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2045-2322
pubs.funder-project-idEconomic and Social Research Council (ES/N00048X/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (ES/N00048X/1, ES/N00048X/1)


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)