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dc.contributor.authorSala-Bayo, Júlia
dc.contributor.authorFiddian, Leanne
dc.contributor.authorNilsson, Simon R. O.
dc.contributor.authorHervig, Mona E.
dc.contributor.authorMcKenzie, Colin
dc.contributor.authorMareschi, Alexis
dc.contributor.authorBoulos, Maria
dc.contributor.authorZhukovsky, Peter
dc.contributor.authorNicholson, Janet
dc.contributor.authorDalley, Jeffrey W.
dc.contributor.authorAlsiö, Johan
dc.contributor.authorRobbins, Trevor W.
dc.date.accessioned2021-01-14T16:19:41Z
dc.date.available2021-01-14T16:19:41Z
dc.date.issued2020-01-15
dc.date.submitted2019-07-18
dc.identifier.issn0893-133X
dc.identifier.others41386-020-0612-4
dc.identifier.other612
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316183
dc.descriptionFunder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi.org/10.13039/501100000268
dc.descriptionFunder: No personal funding for this project
dc.descriptionFunder: GlaxoSmithKline foundation (GSK); doi: https://doi.org/10.13039/501100002066
dc.descriptionFunder: Shionogi (Shionogi & Co. Ltd.); doi: https://doi.org/10.13039/501100005612
dc.description.abstractAbstract: Impaired cognitive flexibility in visual reversal-learning tasks has been observed in a wide range of neurological and neuropsychiatric disorders. Although both human and animal studies have implicated striatal D2-like and D1-like receptors (D2R; D1R) in this form of flexibility, less is known about the contribution they make within distinct sub-regions of the striatum and the different phases of visual reversal learning. The present study investigated the involvement of D2R and D1R during the early (perseverative) phase of reversal learning as well as in the intermediate and late stages (new learning) after microinfusions of D2R and D1R antagonists into the nucleus accumbens core and shell (NAcC; NAcS), the anterior and posterior dorsomedial striatum (DMS) and the dorsolateral striatum (DLS) on a touchscreen visual serial reversal-learning task. Reversal learning was improved after dopamine receptor blockade in the nucleus accumbens; the D1R antagonist, SCH23390, in the NAcS and the D2R antagonist, raclopride, in the NAcC selectively reduced early, perseverative errors. In contrast, reversal learning was impaired by D2R antagonism, but not D1R antagonism, in the dorsal striatum: raclopride increased errors in the intermediate phase after DMS infusions, and increased errors across phases after DLS infusions. These findings indicate that D1R and D2R modulate different stages of reversal learning through effects localised to different sub-regions of the striatum. Thus, deficits in behavioral flexibility observed in disorders linked to dopamine perturbations may be attributable to specific D1R and D2R dysfunction in distinct striatal sub-regions.
dc.languageen
dc.publisherSpringer International Publishing
dc.subjectArticle
dc.subject/631/378/2649
dc.subject/631/477
dc.subject/692/699/476
dc.subject/631/378/1595
dc.subjectarticle
dc.titleDorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning
dc.typeArticle
dc.date.updated2021-01-14T16:19:41Z
prism.endingPage744
prism.issueIdentifier5
prism.publicationNameNeuropsychopharmacology
prism.startingPage736
prism.volume45
dc.identifier.doi10.17863/CAM.63291
dcterms.dateAccepted2019-12-16
rioxxterms.versionofrecord10.1038/s41386-020-0612-4
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidRobbins, Trevor W. [0000-0003-0642-5977]
dc.identifier.eissn1740-634X
pubs.funder-project-idLundbeckfonden (Lundbeck Foundation) (R182-2014-2810)
pubs.funder-project-idWellcome Trust (Wellcome) (104631/14/Z)


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