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dc.contributor.authorEscala-Garcia, Maria
dc.contributor.authorAbraham, Jean
dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorArndt, Volker
dc.contributor.authorAshworth, Alan
dc.contributor.authorAuer, Paul L.
dc.contributor.authorAuvinen, Päivi
dc.contributor.authorBeckmann, Matthias W.
dc.contributor.authorBeesley, Jonathan
dc.contributor.authorBehrens, Sabine
dc.contributor.authorBenitez, Javier
dc.contributor.authorBermisheva, Marina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorBlot, William
dc.contributor.authorBogdanova, Natalia V.
dc.contributor.authorBojesen, Stig E.
dc.contributor.authorBolla, Manjeet K.
dc.contributor.authorBørresen-Dale, Anne-Lise
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBrucker, Sara Y.
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorCaldas, Carlos
dc.contributor.authorCanzian, Federico
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorChin, Suet-Feung
dc.contributor.authorClarke, Christine L.
dc.contributor.authorCouch, Fergus J.
dc.contributor.authorCox, Angela
dc.contributor.authorCross, Simon S.
dc.contributor.authorCzene, Kamila
dc.contributor.authorDaly, Mary B.
dc.contributor.authorDennis, Joe
dc.contributor.authorDevilee, Peter
dc.contributor.authorDunn, Janet A.
dc.contributor.authorDunning, Alison M.
dc.contributor.authorDwek, Miriam
dc.contributor.authorEarl, Helena M.
dc.contributor.authorEccles, Diana M.
dc.contributor.authorEliassen, A. Heather
dc.contributor.authorEllberg, Carolina
dc.contributor.authorEvans, D. Gareth
dc.contributor.authorFasching, Peter A.
dc.contributor.authorFigueroa, Jonine
dc.contributor.authorFlyger, Henrik
dc.contributor.authorGago-Dominguez, Manuela
dc.contributor.authorGapstur, Susan M.
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorGarcía-Sáenz, José A.
dc.contributor.authorGaudet, Mia M.
dc.contributor.authorGeorge, Angela
dc.contributor.authorGiles, Graham G.
dc.contributor.authorGoldgar, David E.
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorGrip, Mervi
dc.contributor.authorGuénel, Pascal
dc.contributor.authorGuo, Qi
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorHåkansson, Niclas
dc.contributor.authorHamann, Ute
dc.contributor.authorHarrington, Patricia A.
dc.contributor.authorHiller, Louise
dc.contributor.authorHooning, Maartje J.
dc.contributor.authorHopper, John L.
dc.contributor.authorHowell, Anthony
dc.contributor.authorHuang, Chiun-Sheng
dc.contributor.authorHuang, Guanmengqian
dc.contributor.authorHunter, David J.
dc.contributor.authorJakubowska, Anna
dc.contributor.authorJohn, Esther M.
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKapoor, Pooja Middha
dc.contributor.authorKeeman, Renske
dc.contributor.authorKitahara, Cari M.
dc.contributor.authorKoppert, Linetta B.
dc.contributor.authorKraft, Peter
dc.contributor.authorKristensen, Vessela N.
dc.contributor.authorLambrechts, Diether
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorLejbkowicz, Flavio
dc.contributor.authorLindblom, Annika
dc.contributor.authorLubiński, Jan
dc.contributor.authorMannermaa, Arto
dc.contributor.authorManoochehri, Mehdi
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorMargolin, Sara
dc.contributor.authorMartinez, Maria Elena
dc.contributor.authorMaurer, Tabea
dc.contributor.authorMavroudis, Dimitrios
dc.contributor.authorMeindl, Alfons
dc.contributor.authorMilne, Roger L.
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorNeuhausen, Susan L.
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorNewman, William G.
dc.contributor.authorOlshan, Andrew F.
dc.contributor.authorOlson, Janet E.
dc.contributor.authorOlsson, Håkan
dc.contributor.authorOrr, Nick
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorPetridis, Christos
dc.contributor.authorPrentice, Ross L.
dc.contributor.authorPresneau, Nadege
dc.contributor.authorPunie, Kevin
dc.contributor.authorRamachandran, Dhanya
dc.contributor.authorRennert, Gad
dc.contributor.authorRomero, Atocha
dc.contributor.authorSachchithananthan, Mythily
dc.contributor.authorSaloustros, Emmanouil
dc.contributor.authorSawyer, Elinor J.
dc.contributor.authorSchmutzler, Rita K.
dc.contributor.authorSchwentner, Lukas
dc.contributor.authorScott, Christopher
dc.contributor.authorSimard, Jacques
dc.contributor.authorSohn, Christof
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorSwerdlow, Anthony J.
dc.contributor.authorTamimi, Rulla M.
dc.contributor.authorTapper, William J.
dc.contributor.authorTeixeira, Manuel R.
dc.contributor.authorTerry, Mary Beth
dc.contributor.authorThorne, Heather
dc.contributor.authorTollenaar, Rob A. E. M.
dc.contributor.authorTomlinson, Ian
dc.contributor.authorTroester, Melissa A.
dc.contributor.authorTruong, Thérèse
dc.contributor.authorTurnbull, Clare
dc.contributor.authorVachon, Celine M.
dc.contributor.authorvan der Kolk, Lizet E.
dc.contributor.authorWang, Qin
dc.contributor.authorWinqvist, Robert
dc.contributor.authorWolk, Alicja
dc.contributor.authorYang, Xiaohong R.
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorPharoah, Paul D. P.
dc.contributor.authorHall, Per
dc.contributor.authorWessels, Lodewyk F. A.
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorBader, Gary D.
dc.contributor.authorDörk, Thilo
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorCanisius, Sander
dc.contributor.authorSchmidt, Marjanka K.
dc.date.accessioned2021-01-15T16:16:06Z
dc.date.available2021-01-15T16:16:06Z
dc.date.issued2020-01-16
dc.date.submitted2019-01-31
dc.identifier.others41467-019-14100-6
dc.identifier.other14100
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316247
dc.description.abstractAbstract: Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/114
dc.subject/631/208/205/2138
dc.subject/692/4028/67/1347
dc.subject/45
dc.subject/45/43
dc.subjectarticle
dc.titleA network analysis to identify mediators of germline-driven differences in breast cancer prognosis
dc.typeArticle
dc.date.updated2021-01-15T16:16:05Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume11
dc.identifier.doi10.17863/CAM.63356
dcterms.dateAccepted2019-12-17
rioxxterms.versionofrecord10.1038/s41467-019-14100-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidAndrulis, Irene L. [0000-0002-4226-6435]
dc.contributor.orcidArndt, Volker [0000-0001-9320-8684]
dc.contributor.orcidBojesen, Stig E. [0000-0002-4061-4133]
dc.contributor.orcidBrauch, Hiltrud [0000-0001-7531-2736]
dc.contributor.orcidCaldas, Carlos [0000-0003-3547-1489]
dc.contributor.orcidCanzian, Federico [0000-0002-4261-4583]
dc.contributor.orcidChanock, Stephen J. [0000-0002-2324-3393]
dc.contributor.orcidChin, Suet-Feung [0000-0001-5697-1082]
dc.contributor.orcidDennis, Joe [0000-0003-4591-1214]
dc.contributor.orcidDevilee, Peter [0000-0002-8023-2009]
dc.contributor.orcidDunning, Alison M. [0000-0001-6651-7166]
dc.contributor.orcidDwek, Miriam [0000-0001-7184-2932]
dc.contributor.orcidEllberg, Carolina [0000-0001-7297-0645]
dc.contributor.orcidFasching, Peter A. [0000-0003-4885-8471]
dc.contributor.orcidGarcía-Closas, Montserrat [0000-0003-1033-2650]
dc.contributor.orcidGarcía-Sáenz, José A. [0000-0001-6880-0301]
dc.contributor.orcidGiles, Graham G. [0000-0003-4946-9099]
dc.contributor.orcidGuénel, Pascal [0000-0002-8359-518X]
dc.contributor.orcidHåkansson, Niclas [0000-0001-7673-5554]
dc.contributor.orcidKapoor, Pooja Middha [0000-0001-5503-8215]
dc.contributor.orcidKeeman, Renske [0000-0002-5452-9933]
dc.contributor.orcidKraft, Peter [0000-0002-4472-8103]
dc.contributor.orcidLambrechts, Diether [0000-0002-3429-302X]
dc.contributor.orcidMilne, Roger L. [0000-0001-5764-7268]
dc.contributor.orcidNevanlinna, Heli [0000-0002-0916-2976]
dc.contributor.orcidNewman, William G. [0000-0002-6382-4678]
dc.contributor.orcidOlson, Janet E. [0000-0003-4944-7789]
dc.contributor.orcidOrr, Nick [0000-0003-2866-942X]
dc.contributor.orcidPeterlongo, Paolo [0000-0001-6951-6855]
dc.contributor.orcidPunie, Kevin [0000-0002-1162-7963]
dc.contributor.orcidRamachandran, Dhanya [0000-0001-8139-7799]
dc.contributor.orcidRennert, Gad [0000-0002-8512-068X]
dc.contributor.orcidRomero, Atocha [0000-0002-1634-7397]
dc.contributor.orcidSaloustros, Emmanouil [0000-0002-0485-0120]
dc.contributor.orcidScott, Christopher [0000-0003-1340-0647]
dc.contributor.orcidSimard, Jacques [0000-0001-6906-3390]
dc.contributor.orcidTeixeira, Manuel R. [0000-0002-4896-5982]
dc.contributor.orcidTomlinson, Ian [0000-0003-3037-1470]
dc.contributor.orcidTruong, Thérèse [0000-0002-2943-6786]
dc.contributor.orcidWinqvist, Robert [0000-0003-0932-9104]
dc.contributor.orcidWolk, Alicja [0000-0001-7387-6845]
dc.contributor.orcidZiogas, Argyrios [0000-0003-4529-3727]
dc.contributor.orcidPharoah, Paul D. P. [0000-0001-8494-732X]
dc.contributor.orcidBader, Gary D. [0000-0003-0185-8861]
dc.contributor.orcidDörk, Thilo [0000-0002-9458-0282]
dc.contributor.orcidEaston, Douglas F. [0000-0003-2444-3247]
dc.contributor.orcidCanisius, Sander [0000-0003-3888-8829]
dc.contributor.orcidSchmidt, Marjanka K. [0000-0002-2228-429X]
dc.identifier.eissn2041-1723


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)