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dc.contributor.authorRoe, James M.
dc.contributor.authorVidal-Piñeiro, Didac
dc.contributor.authorSørensen, Øystein
dc.contributor.authorBrandmaier, Andreas M.
dc.contributor.authorDüzel, Sandra
dc.contributor.authorGonzalez, Hector A.
dc.contributor.authorKievit, Rogier A.
dc.contributor.authorKnights, Ethan
dc.contributor.authorKühn, Simone
dc.contributor.authorLindenberger, Ulman
dc.contributor.authorMowinckel, Athanasia M.
dc.contributor.authorNyberg, Lars
dc.contributor.authorPark, Denise C.
dc.contributor.authorPudas, Sara
dc.contributor.authorRundle, Melissa M.
dc.contributor.authorWalhovd, Kristine B.
dc.contributor.authorFjell, Anders M.
dc.contributor.authorWesterhausen, René
dc.contributor.authorMasters, Colin L.
dc.contributor.authorBush, Ashley I.
dc.contributor.authorFowler, Christopher
dc.contributor.authorDarby, David
dc.contributor.authorPertile, Kelly
dc.contributor.authorRestrepo, Carolina
dc.contributor.authorRoberts, Blaine
dc.contributor.authorRobertson, Jo
dc.contributor.authorRumble, Rebecca
dc.contributor.authorRyan, Tim
dc.contributor.authorCollins, Steven
dc.contributor.authorThai, Christine
dc.contributor.authorTrounson, Brett
dc.contributor.authorLennon, Kate
dc.contributor.authorLi, Qiao-Xin
dc.contributor.authorUgarte, Fernanda Yevenes
dc.contributor.authorVolitakis, Irene
dc.contributor.authorVovos, Michael
dc.contributor.authorWilliams, Rob
dc.contributor.authorBaker, Jenalle
dc.contributor.authorRussell, Alyce
dc.contributor.authorPeretti, Madeline
dc.contributor.authorMilicic, Lidija
dc.contributor.authorLim, Lucy
dc.contributor.authorRodrigues, Mark
dc.contributor.authorTaddei, Kevin
dc.contributor.authorTaddei, Tania
dc.contributor.authorHone, Eugene
dc.contributor.authorLim, Florence
dc.contributor.authorFernandez, Shane
dc.contributor.authorRainey-Smith, Stephanie
dc.contributor.authorPedrini, Steve
dc.contributor.authorMartins, Ralph
dc.contributor.authorDoecke, James
dc.contributor.authorBourgeat, Pierrick
dc.contributor.authorFripp, Jurgen
dc.contributor.authorGibson, Simon
dc.contributor.authorLeroux, Hugo
dc.contributor.authorHanson, David
dc.contributor.authorDore, Vincent
dc.contributor.authorZhang, Ping
dc.contributor.authorBurnham, Samantha
dc.contributor.authorRowe, Christopher C.
dc.contributor.authorVillemagne, Victor L.
dc.contributor.authorYates, Paul
dc.contributor.authorPejoska, Sveltana Bozin
dc.contributor.authorJones, Gareth
dc.contributor.authorAmes, David
dc.contributor.authorCyarto, Elizabeth
dc.contributor.authorLautenschlager, Nicola
dc.contributor.authorBarnham, Kevin
dc.contributor.authorCheng, Lesley
dc.contributor.authorHill, Andy
dc.contributor.authorKilleen, Neil
dc.contributor.authorMaruff, Paul
dc.contributor.authorSilbert, Brendan
dc.contributor.authorBrown, Belinda
dc.contributor.authorSohrabi, Harmid
dc.contributor.authorSavage, Greg
dc.contributor.authorVacher, Michael
dc.date.accessioned2021-02-01T16:06:52Z
dc.date.available2021-02-01T16:06:52Z
dc.date.issued2021-02-01
dc.date.submitted2020-06-25
dc.identifier.others41467-021-21057-y
dc.identifier.other21057
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316932
dc.description.abstractAbstract: Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/378/2612
dc.subject/631/378/1689/1283
dc.subject/631/378/2611
dc.subject/59/57
dc.subjectarticle
dc.titleAsymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
dc.typeArticle
dc.date.updated2021-02-01T16:06:51Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume12
dc.identifier.doi10.17863/CAM.64045
dcterms.dateAccepted2021-01-06
rioxxterms.versionofrecord10.1038/s41467-021-21057-y
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidVidal-Piñeiro, Didac [0000-0001-9997-9156]
dc.contributor.orcidSørensen, Øystein [0000-0003-0724-3542]
dc.contributor.orcidBrandmaier, Andreas M. [0000-0001-8765-6982]
dc.contributor.orcidKievit, Rogier A. [0000-0003-0700-4568]
dc.contributor.orcidLindenberger, Ulman [0000-0001-8428-6453]
dc.contributor.orcidPudas, Sara [0000-0001-9512-3289]
dc.contributor.orcidWalhovd, Kristine B. [0000-0003-1918-1123]
dc.contributor.orcidWesterhausen, René [0000-0001-7107-2712]
dc.identifier.eissn2041-1723


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)