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dc.contributor.authorBell, Steven
dc.contributor.authorRigas, Andreas S.
dc.contributor.authorMagnusson, Magnus K.
dc.contributor.authorFerkingstad, Egil
dc.contributor.authorAllara, Elias
dc.contributor.authorBjornsdottir, Gyda
dc.contributor.authorRamond, Anna
dc.contributor.authorSørensen, Erik
dc.contributor.authorHalldorsson, Gisli H.
dc.contributor.authorPaul, Dirk S.
dc.contributor.authorBurgdorf, Kristoffer S.
dc.contributor.authorEggertsson, Hannes P.
dc.contributor.authorHowson, Joanna M. M.
dc.contributor.authorThørner, Lise W.
dc.contributor.authorKristmundsdottir, Snaedis
dc.contributor.authorAstle, William J.
dc.contributor.authorErikstrup, Christian
dc.contributor.authorSigurdsson, Jon K.
dc.contributor.authorVuckovic, Dragana
dc.contributor.authorDinh, Khoa M.
dc.contributor.authorTragante, Vinicius
dc.contributor.authorSurendran, Praveen
dc.contributor.authorPedersen, Ole B.
dc.contributor.authorVidarsson, Brynjar
dc.contributor.authorJiang, Tao
dc.contributor.authorPaarup, Helene M.
dc.contributor.authorOnundarson, Pall T.
dc.contributor.authorAkbari, Parsa
dc.contributor.authorNielsen, Kaspar R.
dc.contributor.authorLund, Sigrun H.
dc.contributor.authorJuliusson, Kristinn
dc.contributor.authorMagnusson, Magnus I.
dc.contributor.authorFrigge, Michael L.
dc.contributor.authorOddsson, Asmundur
dc.contributor.authorOlafsson, Isleifur
dc.contributor.authorKaptoge, Stephen
dc.contributor.authorHjalgrim, Henrik
dc.contributor.authorRunarsson, Gudmundur
dc.contributor.authorWood, Angela M.
dc.contributor.authorJonsdottir, Ingileif
dc.contributor.authorHansen, Thomas F.
dc.contributor.authorSigurdardottir, Olof
dc.contributor.authorStefansson, Hreinn
dc.contributor.authorRye, David
dc.contributor.authorPeters, James E.
dc.contributor.authorWestergaard, David
dc.contributor.authorHolm, Hilma
dc.contributor.authorSoranzo, Nicole
dc.contributor.authorBanasik, Karina
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorOuwehand, Willem H.
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorRoberts, David J.
dc.contributor.authorSulem, Patrick
dc.contributor.authorButterworth, Adam S.
dc.contributor.authorGudbjartsson, Daniel F.
dc.contributor.authorDanesh, John
dc.contributor.authorBrunak, Søren
dc.contributor.authorDi Angelantonio, Emanuele
dc.contributor.authorUllum, Henrik
dc.contributor.authorStefansson, Kari
dc.contributor.authorAndersen, Steffen
dc.contributor.authorBurgdorf, Kristoffer
dc.contributor.authorJemec, Gregor
dc.contributor.authorJennum, Poul
dc.contributor.authorJohansson, Pär
dc.contributor.authorNielsen, Kasper R.
dc.contributor.authorNyegaard, Mette
dc.contributor.authorPetersen, Mikkel
dc.contributor.authorWerge, Thomas
dc.contributor.authorStefánsson, Hreinn
dc.contributor.authorThorsteinsdóttir, Unnur
dc.date.accessioned2021-02-03T16:16:12Z
dc.date.available2021-02-03T16:16:12Z
dc.date.issued2021-02-03
dc.date.submitted2020-05-19
dc.identifier.others42003-020-01575-z
dc.identifier.other1575
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317086
dc.description.abstractAbstract: Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430), iron (N = 163,511) and transferrin saturation (N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/208/457/649
dc.subject/692/308/2056
dc.subject/45
dc.subject/45/43
dc.subjectarticle
dc.titleA genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
dc.typeArticle
dc.date.updated2021-02-03T16:16:11Z
prism.issueIdentifier1
prism.publicationNameCommunications Biology
prism.volume4
dc.identifier.doi10.17863/CAM.64196
dcterms.dateAccepted2020-12-07
rioxxterms.versionofrecord10.1038/s42003-020-01575-z
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBell, Steven [0000-0001-6774-3149]
dc.contributor.orcidMagnusson, Magnus K. [0000-0001-8593-4934]
dc.contributor.orcidFerkingstad, Egil [0000-0001-8090-7988]
dc.contributor.orcidAllara, Elias [0000-0002-1634-8330]
dc.contributor.orcidHalldorsson, Gisli H. [0000-0001-7067-9862]
dc.contributor.orcidPaul, Dirk S. [0000-0002-8230-0116]
dc.contributor.orcidEggertsson, Hannes P. [0000-0002-1674-9978]
dc.contributor.orcidHowson, Joanna M. M. [0000-0001-7618-0050]
dc.contributor.orcidErikstrup, Christian [0000-0001-6551-6647]
dc.contributor.orcidTragante, Vinicius [0000-0002-8223-8957]
dc.contributor.orcidPedersen, Ole B. [0000-0003-2312-5976]
dc.contributor.orcidPaarup, Helene M. [0000-0003-1281-1567]
dc.contributor.orcidAkbari, Parsa [0000-0001-9210-4760]
dc.contributor.orcidLund, Sigrun H. [0000-0002-3806-2296]
dc.contributor.orcidFrigge, Michael L. [0000-0003-2984-535X]
dc.contributor.orcidOddsson, Asmundur [0000-0002-4606-5163]
dc.contributor.orcidJonsdottir, Ingileif [0000-0001-8339-150X]
dc.contributor.orcidHansen, Thomas F. [0000-0001-6703-7762]
dc.contributor.orcidStefansson, Hreinn [0000-0002-9331-6666]
dc.contributor.orcidWestergaard, David [0000-0003-0128-8432]
dc.contributor.orcidHolm, Hilma [0000-0002-9517-6636]
dc.contributor.orcidSoranzo, Nicole [0000-0003-1095-3852]
dc.contributor.orcidBanasik, Karina [0000-0003-2489-2499]
dc.contributor.orcidOuwehand, Willem H. [0000-0002-7744-1790]
dc.contributor.orcidSulem, Patrick [0000-0001-7123-6123]
dc.contributor.orcidButterworth, Adam S. [0000-0002-6915-9015]
dc.contributor.orcidGudbjartsson, Daniel F. [0000-0002-5222-9857]
dc.contributor.orcidBrunak, Søren [0000-0003-0316-5866]
dc.contributor.orcidStefansson, Kari [0000-0003-1676-864X]
dc.identifier.eissn2399-3642
pubs.funder-project-idDH | NIHR | Health Services Research Programme (NIHR Health Services Research Programme) (NIHR BTRU-2014-10024, NIHR BTRU-2014-10024)
pubs.funder-project-idDH | National Institute for Health Research (NIHR) (Senior Investigator Award)
pubs.funder-project-idBritish Heart Foundation (BHF) (RG/18/13/33946)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)