Show simple item record

dc.contributor.authorYuan, Yuan
dc.contributor.authorJu, Young Seok
dc.contributor.authorKim, Youngwook
dc.contributor.authorLi, Jun
dc.contributor.authorWang, Yumeng
dc.contributor.authorYoon, Christopher J.
dc.contributor.authorYang, Yang
dc.contributor.authorMartincorena, Inigo
dc.contributor.authorCreighton, Chad J.
dc.contributor.authorWeinstein, John N.
dc.contributor.authorXu, Yanxun
dc.contributor.authorHan, Leng
dc.contributor.authorKim, Hyung-Lae
dc.contributor.authorNakagawa, Hidewaki
dc.contributor.authorPark, Keunchil
dc.contributor.authorCampbell, Peter J.
dc.contributor.authorLiang, Han
dc.date.accessioned2021-02-04T16:24:53Z
dc.date.available2021-02-04T16:24:53Z
dc.date.issued2020-02-05
dc.date.submitted2017-09-21
dc.identifier.issn1061-4036
dc.identifier.others41588-019-0557-x
dc.identifier.other557
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317151
dc.description.abstractAbstract: Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we performed a multidimensional, integrated characterization of mitochondrial genomes and related RNA sequencing data. Our analysis presents the most definitive mutational landscape of mitochondrial genomes and identifies several hypermutated cases. Truncating mutations are markedly enriched in kidney, colorectal and thyroid cancers, suggesting oncogenic effects with the activation of signaling pathways. We find frequent somatic nuclear transfers of mitochondrial DNA, some of which disrupt therapeutic target genes. Mitochondrial copy number varies greatly within and across cancers and correlates with clinical variables. Co-expression analysis highlights the function of mitochondrial genes in oxidative phosphorylation, DNA repair and the cell cycle, and shows their connections with clinically actionable genes. Our study lays a foundation for translating mitochondrial biology into clinical applications.
dc.languageen
dc.publisherNature Publishing Group US
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAnalysis
dc.subject/631/67
dc.subject/631/208/212
dc.subject/45/23
dc.subjectanalysis
dc.titleComprehensive molecular characterization of mitochondrial genomes in human cancers
dc.typeArticle
dc.date.updated2021-02-04T16:24:53Z
prism.endingPage352
prism.issueIdentifier3
prism.publicationNameNature Genetics
prism.startingPage342
prism.volume52
dc.identifier.doi10.17863/CAM.64262
dcterms.dateAccepted2019-11-21
rioxxterms.versionofrecord10.1038/s41588-019-0557-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidYuan, Yuan [0000-0003-4706-7897]
dc.contributor.orcidJu, Young Seok [0000-0002-5514-4189]
dc.contributor.orcidKim, Youngwook [0000-0002-1106-3037]
dc.contributor.orcidLi, Jun [0000-0002-1171-7141]
dc.contributor.orcidCreighton, Chad J. [0000-0002-6090-703X]
dc.contributor.orcidWeinstein, John N. [0000-0001-9401-6908]
dc.contributor.orcidHan, Leng [0000-0002-7380-2640]
dc.contributor.orcidPark, Keunchil [0000-0002-4846-7449]
dc.contributor.orcidCampbell, Peter J. [0000-0002-3921-0510]
dc.contributor.orcidLiang, Han [0000-0001-7633-286X]
dc.identifier.eissn1546-1718


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)