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dc.contributor.authorFirbank, Michael J.
dc.contributor.authorO’Brien, John T.
dc.contributor.authorDurcan, Rory
dc.contributor.authorAllan, Louise M.
dc.contributor.authorBarker, Sally
dc.contributor.authorCiafone, Joanna
dc.contributor.authorDonaghy, Paul C.
dc.contributor.authorHamilton, Calum A.
dc.contributor.authorLawley, Sarah
dc.contributor.authorLloyd, Jim
dc.contributor.authorRoberts, Gemma
dc.contributor.authorTaylor, John-Paul
dc.contributor.authorThomas, Alan J.
dc.date.accessioned2021-03-24T16:11:08Z
dc.date.available2021-03-24T16:11:08Z
dc.date.issued2020-10-21
dc.date.submitted2020-08-25
dc.identifier.issn0340-5354
dc.identifier.others00415-020-10271-1
dc.identifier.other10271
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319142
dc.descriptionFunder: GE Healthcare; doi: http://dx.doi.org/10.13039/100006775
dc.descriptionFunder: NIHR Newcastle Biomedical Research Centre; doi: http://dx.doi.org/10.13039/501100012295
dc.descriptionFunder: Newcastle University
dc.description.abstractAbstract: Objective: To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. Methods: We obtained perfusion images on 32 MCI-LB, 30 MCI-AD and 28 healthy subjects of similar age. Perfusion relative to cerebellum was calculated, and we aimed to examine differences in relative perfusion between MCI-LB and the other groups. This included whole brain voxelwise comparisons, as well as using predefined region-of-interest ratios of medial occipital to medial temporal, and posterior cingulate to precuneus. Differences in occipital perfusion in eyes open vs eyes closed conditions were also examined. Results: Compared to controls, the MCI-LB showed reduced perfusion in the precuneus, parietal, occipital and fusiform gyrus regions. In our predefined regions, the ratio of perfusion in occipital/medial temporal was significantly lower, and the posterior cingulate/precuneus ratio was significantly higher in MCI-LB compared to controls. Overall, the occipital perfusion was greater in the eyes open vs closed condition, but this did not differ between groups. Conclusion: We found patterns of altered perfusion in MCI-LB which are similar to those seen in dementia with Lewy bodies, with reduction in posterior parietal and occipital regions, but relatively preserved posterior cingulate.
dc.languageen
dc.publisherSpringer Berlin Heidelberg
dc.subjectOriginal Communication
dc.subjectMild cognitive impairment
dc.subjectMagnetic resonance imaging
dc.subjectPerfusion imaging
dc.subjectArterial spin labelling
dc.subjectLewy body disease
dc.titleMild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling
dc.typeArticle
dc.date.updated2021-03-24T16:11:07Z
prism.endingPage1294
prism.issueIdentifier4
prism.publicationNameJournal of Neurology
prism.startingPage1284
prism.volume268
dc.identifier.doi10.17863/CAM.66261
dcterms.dateAccepted2020-10-10
rioxxterms.versionofrecord10.1007/s00415-020-10271-1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidFirbank, Michael J. [0000-0002-9536-0185]
dc.identifier.eissn1432-1459
pubs.funder-project-idAlzheimer’s Research UK (ARUK-PG3026-13)


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