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dc.contributor.authorAlmaani, Salem
dc.contributor.authorFussner, Lynn A.
dc.contributor.authorBrodsky, Sergey
dc.contributor.authorMeara, Alexa S.
dc.contributor.authorJayne, David
dc.date.accessioned2021-04-04T07:22:25Z
dc.date.available2021-04-04T07:22:25Z
dc.date.issued2021-04-01
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319467
dc.description.abstractAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) represents a group of small vessel vasculitides characterized by granulomatous and neutrophilic tissue inflammation, often associated with the production of antibodies that target neutrophil antigens. The two major antigens targeted by ANCAs are leukocyte proteinase 3 (PR3) and myeloperoxidase (MPO). AAV can be classified into 3 categories based on patterns of clinical involvement: namely, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic GPA (EGPA). Clinically, AAV involves many organ systems including the lungs, kidneys, skin, and nervous system. The prognosis of AAV has improved dramatically due to advances in the understanding of its pathogenesis and treatment modalities. This review will highlight some of the recent updates in our understanding of the pathogenesis, clinical manifestations, and treatment options in patients with AAV focusing on kidney involvement.
dc.languageen
dc.publisherMDPI
dc.subjectANCA vasculitis
dc.subjectreview
dc.subjectvasculitis
dc.subjectcrescentic glomerulonephritis
dc.titleANCA-Associated Vasculitis: An Update
dc.typeArticle
dc.date.updated2021-04-04T07:22:24Z
prism.issueIdentifier7
prism.publicationNameJournal of Clinical Medicine
prism.volume10
dc.identifier.doi10.17863/CAM.66589
dcterms.dateAccepted2021-03-25
rioxxterms.versionofrecord10.3390/jcm10071446
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidAlmaani, Salem [0000-0003-2271-500X]
dc.identifier.eissn2077-0383


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