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dc.contributor.authorZakrzewski, Przemysław
dc.contributor.authorLenartowska, Marta
dc.contributor.authorBuss, Folma
dc.date.accessioned2021-04-05T15:32:10Z
dc.date.available2021-04-05T15:32:10Z
dc.date.issued2021-01-02
dc.identifier.issn0948-6143
dc.identifier.others00418-020-01954-x
dc.identifier.other1954
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319471
dc.description.abstractAbstract: Spermiogenesis is the final stage of spermatogenesis, a differentiation process during which unpolarized spermatids undergo excessive remodeling that results in the formation of sperm. The actin cytoskeleton and associated actin-binding proteins play crucial roles during this process regulating organelle or vesicle delivery/segregation and forming unique testicular structures involved in spermatid remodeling. In addition, several myosin motor proteins including MYO6 generate force and movement during sperm differentiation. MYO6 is highly unusual as it moves towards the minus end of actin filaments in the opposite direction to other myosin motors. This specialized feature of MYO6 may explain the many proposed functions of this myosin in a wide array of cellular processes in animal cells, including endocytosis, secretion, stabilization of the Golgi complex, and regulation of actin dynamics. These diverse roles of MYO6 are mediated by a range of specialized cargo-adaptor proteins that link this myosin to distinct cellular compartments and processes. During sperm development in a number of different organisms, MYO6 carries out pivotal functions. In Drosophila, the MYO6 ortholog regulates actin reorganization during spermatid individualization and male KO flies are sterile. In C. elegans, the MYO6 ortholog mediates asymmetric segregation of cytosolic material and spermatid budding through cytokinesis, whereas in mice, this myosin regulates assembly of highly specialized actin-rich structures and formation of membrane compartments to allow the formation of fully differentiated sperm. In this review, we will present an overview and compare the diverse function of MYO6 in the specialized adaptations of spermiogenesis in flies, worms, and mammals.
dc.languageen
dc.publisherSpringer Berlin Heidelberg
dc.subjectReview
dc.subjectActin
dc.subjectC. elegans
dc.subjectDrosophila
dc.subjectMouse
dc.subjectMyosin VI
dc.subjectSpermiogenesis
dc.titleDiverse functions of myosin VI in spermiogenesis
dc.typeArticle
dc.date.updated2021-04-05T15:32:10Z
prism.endingPage340
prism.issueIdentifier3
prism.publicationNameHistochemistry and Cell Biology
prism.startingPage323
prism.volume155
dc.identifier.doi10.17863/CAM.66594
dcterms.dateAccepted2020-12-02
rioxxterms.versionofrecord10.1007/s00418-020-01954-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBuss, Folma [0000-0003-4457-3479]
dc.identifier.eissn1432-119X
pubs.funder-project-idNarodowym Centrum Nauki (2017/25/N/NZ3/00487)
pubs.funder-project-idNarodowe Centrum Nauki (2018/28/T/NZ3/00002)
pubs.funder-project-idCompany of Biologists (JCSTF-171105)
pubs.funder-project-idMedical Research Council (MR/K000888/1)
pubs.funder-project-idWellcome Trust (100140, 093026)


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