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dc.contributor.authorWood, Angela
dc.contributor.authorDenholm, Rachel
dc.contributor.authorHollings, Sam
dc.contributor.authorCooper, Jennifer
dc.contributor.authorIp, Samantha
dc.contributor.authorWalker, Venexia
dc.contributor.authorDenaxas, Spiros
dc.contributor.authorAkbari, Ashley
dc.contributor.authorBanerjee, Amitava
dc.contributor.authorWhiteley, William
dc.contributor.authorLai, Alvina
dc.contributor.authorSterne, Jonathan
dc.contributor.authorSudlow, Cathie
dc.contributor.authorCVD-COVID-UK consortium
dc.contributor.authorDouiri, Abdel
dc.contributor.authorAkinoso-Imran, Abdul Qadr
dc.contributor.authorJonas, Adrian
dc.contributor.authorShah, Ajay
dc.contributor.authorHandy, Alex
dc.contributor.authorDavies, Alun
dc.contributor.authorKurdi, Amanj
dc.contributor.authorHansell, Anna
dc.contributor.authorDocherty, Annemarie
dc.contributor.authorPherwani, Arun
dc.contributor.authorDashtban, Ashkan
dc.contributor.authorBray, Ben
dc.contributor.authorCairns, Ben
dc.contributor.authorGoldacre, Ben
dc.contributor.authorHumberstone, Ben
dc.contributor.authorMateen, Bilal
dc.contributor.authorDoble, Brett
dc.contributor.authorRoberts, Brian
dc.contributor.authorMorris, Carole
dc.contributor.authorDale, Caroline
dc.contributor.authorRogers, Caroline
dc.contributor.authorWolfe, Charles
dc.contributor.authorTomlinson, Christopher
dc.contributor.authorLawson, Claire
dc.contributor.authordu Toit, Clea
dc.contributor.authorBerry, Colin
dc.contributor.authorSmith, Craig
dc.contributor.authorO’Connell, Dan
dc.contributor.authorHarris, Daniel
dc.contributor.authorBrind, David
dc.contributor.authorCromwell, David
dc.contributor.authorHughes, David
dc.contributor.authorMartos, David Moreno
dc.contributor.authorRingham, Debbie
dc.contributor.authorLawler, Deborah
dc.contributor.authorLowe, Deborah
dc.contributor.authorNikiphorou, Elena
dc.contributor.authorWithnell, Eloise
dc.contributor.authorDi Angelantonio, Emanuele
dc.contributor.authorMorris, Eva
dc.contributor.authorBirney, Ewan
dc.contributor.authorFalck, Fabian
dc.contributor.authorTorabi, Fatemeh
dc.contributor.authorGreaves, Felix
dc.contributor.authorFalter, Florian
dc.contributor.authorZaccardi, Francesco
dc.contributor.authorKee, Frank
dc.contributor.authorDavies, Gareth
dc.contributor.authorNicholson, George
dc.contributor.authorCurry, Gwenetta
dc.contributor.authorZhang, Haoting
dc.contributor.authorHemingway, Harry
dc.contributor.authorWilde, Harry
dc.contributor.authorAbbasizanjani, Hoda
dc.contributor.authorWu, Honghan
dc.contributor.authorTang, Howard
dc.contributor.authorWang, Huan
dc.contributor.authorMordi, Ify
dc.contributor.authorMacArthur, Jackie
dc.contributor.authorLyons, Jane
dc.contributor.authorBeveridge, Jennifer
dc.contributor.authorBarrett, Jessica
dc.contributor.authorWu, Jianhua
dc.contributor.authorThygesen, Johan
dc.contributor.authorDanesh, John
dc.contributor.authorDennis, John
dc.contributor.authorBoyle, Jon
dc.contributor.authorHalcox, Julian
dc.contributor.authorKhunti, Kamlesh
dc.contributor.authorCheema, Kate
dc.contributor.authorBrown, Katherine
dc.contributor.authorLi, Ken
dc.contributor.authorKavanagh, Kim
dc.contributor.authorNorth, Laura
dc.contributor.authorPasea, Laura
dc.contributor.authorEllins, Libby
dc.contributor.authorPierotti, Livia
dc.contributor.authorWright, Lucy
dc.contributor.authorMartin, Lydia
dc.contributor.authorMorrice, Lynn
dc.contributor.authorMamas, Mamas
dc.contributor.authorBennie, Marion
dc.contributor.authorBarber, Mark
dc.contributor.authorMacleod, Mary Joan
dc.contributor.authorCaputo, Massimo
dc.contributor.authorBuch, Maya
dc.contributor.authorMizani, Mehrdad
dc.contributor.authorKatsoulis, Michalis
dc.contributor.authorGravenor, Mike
dc.contributor.authorInouye, Mike
dc.contributor.authorSkrypak, Mirek
dc.contributor.authorGerstung, Moritz
dc.contributor.authorPirmohamed, Munir
dc.contributor.authorGlickman, Myer
dc.contributor.authorHerz, Naomi
dc.contributor.authorDavies, Neil
dc.contributor.authorHall, Nick
dc.contributor.authorSamani, Nilesh
dc.contributor.authorSeminog, Olena
dc.contributor.authorLorgelly, Paula
dc.contributor.authorMachado, Pedro
dc.contributor.authorLi, Qiuju
dc.contributor.authorGoldacre, Raph
dc.contributor.authorCarragher, Raymond
dc.contributor.authorSofat, Reecha
dc.contributor.authorTakhar, Rohan
dc.contributor.authorLyons, Ronan
dc.contributor.authorPriedon, Rouven
dc.contributor.authorGriffiths, Rowena
dc.contributor.authorPayne, Rupert
dc.contributor.authorKolamunnage-Dona, Ruwanthi
dc.contributor.authorSalim, Safa
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorOnida, Sarah
dc.contributor.authorKent, Seamus
dc.contributor.authorBacon, Seb
dc.contributor.authorManohar, Sinduja
dc.contributor.authorBabu-Narayan, Sonya
dc.contributor.authorKeene, Spencer
dc.contributor.authorVarma, Susheel
dc.contributor.authorLawrence, Thomas
dc.contributor.authorWang, Tianxiao
dc.contributor.authorWilkinson, Tim
dc.contributor.authorNorris, Tom
dc.contributor.authorPalmer, Tom
dc.contributor.authorNafilyan, Vahé
dc.date.accessioned2021-04-08T14:23:48Z
dc.date.available2021-04-08T14:23:48Z
dc.date.issued2021-04-07
dc.identifier.otherwooa065067
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319577
dc.description.abstractAbstract: Objective: To describe a novel England-wide electronic health record (EHR) resource enabling whole population research on covid-19 and cardiovascular disease while ensuring data security and privacy and maintaining public trust. Design: Data resource comprising linked person level records from national healthcare settings for the English population, accessible within NHS Digital’s new trusted research environment. Setting: EHRs from primary care, hospital episodes, death registry, covid-19 laboratory test results, and community dispensing data, with further enrichment planned from specialist intensive care, cardiovascular, and covid-19 vaccination data. Participants: 54.4 million people alive on 1 January 2020 and registered with an NHS general practitioner in England. Main measures of interest: Confirmed and suspected covid-19 diagnoses, exemplar cardiovascular conditions (incident stroke or transient ischaemic attack and incident myocardial infarction) and all cause mortality between 1 January and 31 October 2020. Results: The linked cohort includes more than 96% of the English population. By combining person level data across national healthcare settings, data on age, sex, and ethnicity are complete for around 95% of the population. Among 53.3 million people with no previous diagnosis of stroke or transient ischaemic attack, 98 721 had a first ever incident stroke or transient ischaemic attack between 1 January and 31 October 2020, of which 30% were recorded only in primary care and 4% only in death registry records. Among 53.2 million people with no previous diagnosis of myocardial infarction, 62 966 had an incident myocardial infarction during follow-up, of which 8% were recorded only in primary care and 12% only in death registry records. A total of 959 470 people had a confirmed or suspected covid-19 diagnosis (714 162 in primary care data, 126 349 in hospital admission records, 776 503 in covid-19 laboratory test data, and 50 504 in death registry records). Although 58% of these were recorded in both primary care and covid-19 laboratory test data, 15% and 18%, respectively, were recorded in only one. Conclusions: This population-wide resource shows the importance of linking person level data across health settings to maximise completeness of key characteristics and to ascertain cardiovascular events and covid-19 diagnoses. Although this resource was initially established to support research on covid-19 and cardiovascular disease to benefit clinical care and public health and to inform healthcare policy, it can broaden further to enable a wide range of research.
dc.languageen
dc.publisherBritish Medical Journal Publishing Group
dc.subjectResearch
dc.titleLinked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource
dc.typeArticle
dc.date.updated2021-04-08T14:23:48Z
prism.publicationNameBMJ
prism.volume373
dc.identifier.doi10.17863/CAM.66697
dcterms.dateAccepted2021-03-29
rioxxterms.versionofrecord10.1136/bmj.n826
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1756-1833


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