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dc.contributor.authorBurton, Nicholas O.
dc.contributor.authorRiccio, Cristian
dc.contributor.authorDallaire, Alexandra
dc.contributor.authorPrice, Jonathan
dc.contributor.authorJenkins, Benjamin
dc.contributor.authorKoulman, Albert
dc.contributor.authorMiska, Eric A.
dc.date.accessioned2021-04-08T15:32:04Z
dc.date.available2021-04-08T15:32:04Z
dc.date.issued2020-04-08
dc.date.submitted2019-10-24
dc.identifier.others41467-020-15555-8
dc.identifier.other15555
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319581
dc.description.abstractAbstract: Parental exposure to pathogens can prime offspring immunity in diverse organisms. The mechanisms by which this heritable priming occurs are largely unknown. Here we report that the soil bacteria Pseudomonas vranovensis is a natural pathogen of the nematode Caenorhabditis elegans and that parental exposure of animals to P. vranovensis promotes offspring resistance to infection. Furthermore, we demonstrate a multigenerational enhancement of progeny survival when three consecutive generations of animals are exposed to P. vranovensis. By investigating the mechanisms by which animals heritably adapt to P. vranovensis infection, we found that parental infection by P. vranovensis results in increased expression of the cysteine synthases cysl-1 and cysl-2 and the regulator of hypoxia inducible factor rhy-1 in progeny, and that these three genes are required for adaptation to P. vranovensis. These observations establish a CYSL-1, CYSL-2, and RHY-1 dependent mechanism by which animals heritably adapt to infection.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/631/208/199
dc.subject/631/250/254
dc.subject/631/326/421
dc.subject/38/91
dc.subject/38/35
dc.subject/14/35
dc.subject/64/11
dc.subject/96/63
dc.subjectarticle
dc.titleCysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection
dc.typeArticle
dc.date.updated2021-04-08T15:32:04Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume11
dc.identifier.doi10.17863/CAM.66701
dcterms.dateAccepted2020-03-19
rioxxterms.versionofrecord10.1038/s41467-020-15555-8
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBurton, Nicholas O. [0000-0002-5495-3988]
dc.contributor.orcidDallaire, Alexandra [0000-0003-1097-7766]
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
dc.contributor.orcidMiska, Eric A. [0000-0002-4450-576X]
dc.identifier.eissn2041-1723
pubs.funder-project-idRCUK | Biotechnology and Biological Sciences Research Council (BBSRC) (BB/M027252/1, BB/M027252/1)
pubs.funder-project-idWellcome Trust (Wellcome) (104640/Z/14/Z, 092096/Z/10/Z)
pubs.funder-project-idCancer Research UK (CRUK) (C13474/A18583, C6946/A14492)


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