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dc.contributor.authorMassias, Joseph S
dc.contributor.authorSmith, Eve MD
dc.contributor.authorAl-Abadi, Eslam
dc.contributor.authorArmon, Kate
dc.contributor.authorBailey, Kathryn
dc.contributor.authorCiurtin, Coziana
dc.contributor.authorDavidson, Joyce
dc.contributor.authorGardner-Medwin, Janet
dc.contributor.authorHaslam, Kirsty
dc.contributor.authorHawley, Dan P
dc.contributor.authorLeahy, Alice
dc.contributor.authorLeone, Valentina
dc.contributor.authorMcErlane, Flora
dc.contributor.authorMewar, Devesh
dc.contributor.authorModgil, Gita
dc.contributor.authorMoots, Robert
dc.contributor.authorPilkington, Clarissa
dc.contributor.authorRamanan, Athimalaipet V
dc.contributor.authorRangaraj, Satyapal
dc.contributor.authorRiley, Phil
dc.contributor.authorSridhar, Arani
dc.contributor.authorWilkinson, Nick
dc.contributor.authorBeresford, Michael W
dc.contributor.authorHedrich, Christian M
dc.date.accessioned2021-04-10T18:26:49Z
dc.date.available2021-04-10T18:26:49Z
dc.date.issued2021-01-07
dc.date.submitted2020-09-28
dc.identifier.issn0961-2033
dc.identifier.other10.1177_0961203320984251
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/319718
dc.descriptionFunder: LUPUS UK
dc.description.abstractSystemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease. Patients diagnosed with juvenile-onset SLE (jSLE), when compared to individuals with adult-onset SLE, develop more severe organ involvement, increased disease activity and greater tissue and organ damage. In adult-onset SLE, clinical characteristics, pathomechanisms, disease progression and outcomes do not only vary between individuals and age groups, but also ethnicities. However, in children and young people, the influence of ethnicity on disease onset, phenotype and outcome has not been investigated in detail. In this study, we investigated clinical and laboratory characteristics in pediatric SLE patients from different ethnic backgrounds (White Caucasian, Asian, Black African/Caribbean) accessing data from a national cohort of jSLE patients (the UK JSLE Cohort Study). Among jSLE patients in the UK, ethnicity affects both the disease’s clinical course and outcomes. At diagnosis, Black African/Caribbean jSLE patients show more “classical” laboratory and clinical features when compared to White Caucasian or Asian patients. Black African/Caribbean jSLE patients exhibit more renal involvement and more frequently receive cyclophosphamide and rituximab. Studies targeting ethnicity-specific contributors to disease expression and phenotypes are necessary to improve our pathophysiological understanding, diagnosis and treatment of jSLE.
dc.languageen
dc.publisherSAGE Publications
dc.rightsEmbargo: ends 2021-01-07
dc.subjectPapers
dc.subjectjSLE
dc.subjectlupus
dc.subjectethicity
dc.subjectphenotype
dc.subjectpaediatric
dc.titleClinical and laboratory phenotypes in juvenile-onset Systemic Lupus Erythematosus across ethnicities in the UK
dc.typeArticle
dc.date.updated2021-04-10T18:26:49Z
prism.endingPage607
prism.issueIdentifier4
prism.publicationNameLupus
prism.startingPage597
prism.volume30
dc.identifier.doi10.17863/CAM.66839
dcterms.dateAccepted2020-12-08
rioxxterms.versionofrecord10.1177/0961203320984251
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.licenseref.startdate2021-01-07
dc.contributor.orcidSmith, Eve MD [0000-0002-8371-7597]
dc.contributor.orcidCiurtin, Coziana [0000-0002-8911-4113]
dc.contributor.orcidHedrich, Christian M [0000-0002-1295-6179]
dc.identifier.eissn1477-0962
rioxxterms.freetoread.startdate2021-01-07


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