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dc.contributor.authorWołodko, Karolina
dc.contributor.authorCastillo-Fernandez, Juan
dc.contributor.authorKelsey, Gavin
dc.contributor.authorGalvão, António
dc.date.accessioned2021-04-22T03:33:01Z
dc.date.available2021-04-22T03:33:01Z
dc.date.issued2021-04-20
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/321432
dc.description.abstractThe complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.
dc.languageen
dc.publisherMDPI
dc.subjectleptin
dc.subjectobesity
dc.subjectovary
dc.subjectfolliculogenesis
dc.subjectoocyte
dc.titleRevisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
dc.typeArticle
dc.date.updated2021-04-22T03:33:01Z
prism.issueIdentifier8
prism.publicationNameInternational Journal of Molecular Sciences
prism.volume22
dc.identifier.doi10.17863/CAM.68553
dcterms.dateAccepted2021-04-16
rioxxterms.versionofrecord10.3390/ijms22084270
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWołodko, Karolina [0000-0003-0634-7331]
dc.contributor.orcidCastillo-Fernandez, Juan [0000-0002-0034-8029]
dc.contributor.orcidKelsey, Gavin [0000-0002-9762-5634]
dc.contributor.orcidGalvão, António [0000-0002-7990-3071]
dc.identifier.eissn1422-0067
pubs.funder-project-idPolish National Science Centre (2016/23/B/NZ4/03737, 2019/34/E/NZ4/00349)


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