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dc.contributor.authorBarron, Sarah L.
dc.contributor.authorSaez, Janire
dc.contributor.authorOwens, Róisín M.
dc.date.accessioned2021-05-04T13:10:52Z
dc.date.available2021-05-04T13:10:52Z
dc.date.issued2021-05-04
dc.date.submitted2020-12-07
dc.identifier.issn2701-0198
dc.identifier.otheradbi202000624
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/321905
dc.description.abstractAbstract: Respiratory diseases and lower respiratory tract infections are among the leading cause of death worldwide and, especially given the recent severe acute respiratory syndrome coronavirus‐2 pandemic, are of high and prevalent socio‐economic importance. In vitro models, which accurately represent the lung microenvironment, are of increasing significance given the ethical concerns around animal work and the lack of translation to human disease, as well as the lengthy time to market and the attrition rates associated with clinical trials. This review gives an overview of the biological and immunological components involved in regulating the respiratory epithelium system in health, disease, and infection. The evolution from 2D to 3D cell biology and to more advanced technological integrated models for studying respiratory host–pathogen interactions are reviewed and provide a reference point for understanding the in vitro modeling requirements. Finally, the current limitations and future perspectives for advancing this field are presented.
dc.languageen
dc.subjectReview
dc.subjectReviews
dc.subjecthost–pathogens
dc.subjectimmunology
dc.subjectin vitro models
dc.subjectinfection
dc.subjectlungs
dc.subjectpathogens
dc.subjectrespiratory system
dc.titleIn Vitro Models for Studying Respiratory Host–Pathogen Interactions
dc.typeArticle
dc.date.updated2021-05-04T13:10:51Z
prism.publicationNameAdvanced Biology
dc.identifier.doi10.17863/CAM.69363
rioxxterms.versionofrecord10.1002/adbi.202000624
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidOwens, Róisín M. [0000-0001-7856-2108]
pubs.funder-project-idEngineering and Physical Sciences Research Council Centre for Doctoral Training in Sensor Technologies and Applications (EP/L015889/1)
pubs.funder-project-idEuropean Union's Horizon 2020 Research and Innovation Programme under the Marie Skłodowska‐Curie (842356)


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