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dc.contributor.authorMazumder, Atiqul Haq
dc.contributor.authorBarnett, Jennifer
dc.contributor.authorLindberg, Nina
dc.contributor.authorTorniainen-Holm, Minna
dc.contributor.authorLähteenvuo, Markku
dc.contributor.authorLahdensuo, Kaisla
dc.contributor.authorKerkelä, Martta
dc.contributor.authorHietala, Jarmo
dc.contributor.authorIsometsä, Erkki Tapio
dc.contributor.authorKampman, Olli
dc.contributor.authorKieseppä, Tuula
dc.contributor.authorJukuri, Tuomas
dc.contributor.authorHäkkinen, Katja
dc.contributor.authorCederlöf, Erik
dc.contributor.authorHaaki, Willehard
dc.contributor.authorKajanne, Risto
dc.contributor.authorWegelius, Asko
dc.contributor.authorMännynsalo, Teemu
dc.contributor.authorNiemi-Pynttäri, Jussi
dc.contributor.authorSuokas, Kimmo
dc.contributor.authorLönnqvist, Jouko
dc.contributor.authorNiemelä, Solja
dc.contributor.authorTiihonen, Jari
dc.contributor.authorPaunio, Tiina
dc.contributor.authorPalotie, Aarno
dc.contributor.authorSuvisaari, Jaana
dc.contributor.authorVeijola, Juha
dc.date.accessioned2021-07-07T13:59:05Z
dc.date.available2021-07-07T13:59:05Z
dc.date.issued2021-05-23
dc.identifier.issn2076-3425
dc.identifier.otherPMC8224767
dc.identifier.other34071123
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/324845
dc.description.abstractThe purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2076-3425
dc.sourcenlmid: 101598646
dc.subjectSchizophrenia
dc.subjectAlcohol
dc.subjectCognition
dc.subjectReaction time
dc.subjectSchizoaffective Disorder
dc.subjectVisual Memory
dc.titleReaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder.
dc.typeArticle
dc.date.updated2021-07-07T13:59:04Z
prism.issueIdentifier6
prism.publicationNameBrain sciences
prism.volume11
dc.identifier.doi10.17863/CAM.72299
rioxxterms.versionofrecord10.3390/brainsci11060688
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidMazumder, Atiqul Haq [0000-0002-2148-4070]
dc.contributor.orcidLähteenvuo, Markku [0000-0002-7244-145X]
dc.contributor.orcidKerkelä, Martta [0000-0002-1181-2632]
dc.contributor.orcidHietala, Jarmo [0000-0002-3179-6780]
dc.contributor.orcidIsometsä, Erkki Tapio [0000-0001-5956-2399]
dc.contributor.orcidKampman, Olli [0000-0001-6891-2266]
dc.contributor.orcidHäkkinen, Katja [0000-0001-8222-7505]
dc.contributor.orcidHaaki, Willehard [0000-0002-2850-7650]
dc.contributor.orcidKajanne, Risto [0000-0002-3405-7115]
dc.contributor.orcidSuokas, Kimmo [0000-0001-6296-6343]
dc.contributor.orcidNiemelä, Solja [0000-0003-1130-9161]
dc.contributor.orcidTiihonen, Jari [0000-0002-0400-6798]
dc.contributor.orcidPaunio, Tiina [0000-0002-5560-0666]
dc.contributor.orcidPalotie, Aarno [0000-0002-2527-5874]
dc.contributor.orcidSuvisaari, Jaana [0000-0001-7167-0990]
dc.contributor.orcidVeijola, Juha [0000-0002-4139-9981]
pubs.funder-project-idH2020 Marie Skłodowska-Curie Actions (713606)
pubs.funder-project-idIso-Mällisen Foundation (Iso-Mällisen Säätiö) (0400 584622)
pubs.funder-project-idStanley Center for Psychiatric Research, Broad Institute (0000-0000)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International