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Strategy for Controlled Protection of Redox-Cycling Ortho-Quinones with Self-Immolative Linkers


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Type

Thesis

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Authors

Abstract

[Restricted]

Description

Date

2021-01-29

Advisors

Bernardes, Gonçalo

Keywords

ortho-quinone, quinone, lapachone, beta-lapachone, prodrug, self-immolative linker, pH dependence, para-aminobenzyl ketol, para-hydroxybenzyl ketol, redox, redox cycling, antibody-drug conjugate, ADC, targeted therapy, acute myeloid leukaemia

Qualification

Doctor of Philosophy (PhD)

Awarding Institution

University of Cambridge
Sponsorship
Biotechnology and Biological Sciences Research Council (1795534)
UKRI BBSRC DTP PhD Studentship (1795534)