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Morphoelasticity of large bending deformations of cell sheets during development.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Haas, Pierre A 
Goldstein, Raymond E 

Abstract

Deformations of cell sheets during morphogenesis are driven by developmental processes such as cell division and cell shape changes. In morphoelastic shell theories of development, these processes appear as variations of the intrinsic geometry of a thin elastic shell. However, morphogenesis often involves large bending deformations that are outside the formal range of validity of these shell theories. Here, by asymptotic expansion of three-dimensional incompressible morphoelasticity in the limit of a thin shell, we derive a shell theory for large intrinsic bending deformations and emphasize the resulting geometric material anisotropy and the elastic role of cell constriction. Taking the invagination of the green alga Volvox as a model developmental event, we show how results for this theory differ from those for a classical shell theory that is not formally valid for these large bending deformations and reveal how these geometric effects stabilize invagination.

Description

Keywords

cond-mat.soft, cond-mat.soft, physics.bio-ph

Journal Title

Phys Rev E

Conference Name

Journal ISSN

2470-0045
2470-0053

Volume Title

103

Publisher

American Physical Society (APS)
Sponsorship
Engineering and Physical Sciences Research Council (EP/M017982/1)
Wellcome Trust (207510/Z/17/Z)
Magdalene College Cambridge: Nevile Research Fellowship