Post-mortem dissection of COVID-19: a pathogenic role for macrophages?
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Peer-reviewed
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Abstract
Acute respiratory failure is the leading cause of death in severe COVID-19. By combining rapid tissue sampling at autopsy with high dimensional analyses, including measurement of immune cells, proteins and RNA, unparalleled insights into the mechanisms of dysregulated inflammation in COVID-19 have been obtained1–4. Here we summarise some of the conceptual advances revealed by post-mortem studies of severe COVID-19, and make particular reference to the apparent dominance of macrophages, how this may relate to disease pathophysiology, and the opportunities for targeted therapeutic intervention.
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Keywords
Autopsy, COVID-19, Dissection, Humans, Macrophages, SARS-CoV-2
Journal Title
Intensive Care Med
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0342-4642
1432-1238
1432-1238
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Springer Science and Business Media LLC
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All rights reserved
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MRC (MR/V006118/1)
ACM is supported by a Medical Research Council Clinician Scientist Fellowship (MR/V006118/1). CDL is supported by a Wellcome Trust Clinical Research Career Development Fellowship (206566/Z/17/Z) and receives funding from the UKRI-NIHR COVID-19 Call (MR/V028790/1). PPV is supported by a Wellcome Trust PhD Training Fellowship for Clinicians (214179/Z/18/Z).