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dc.contributor.authorBuffenstein, Rochelle
dc.contributor.authorAmoroso, Vincent
dc.contributor.authorAndziak, Blazej
dc.contributor.authorAvdieiev, Stanislav
dc.contributor.authorAzpurua, Jorge
dc.contributor.authorBarker, Alison J.
dc.contributor.authorBennett, Nigel C.
dc.contributor.authorBrieño‐Enríquez, Miguel A.
dc.contributor.authorBronner, Gary N.
dc.contributor.authorCoen, Clive
dc.contributor.authorDelaney, Martha A.
dc.contributor.authorDengler‐Crish, Christine M.
dc.contributor.authorEdrey, Yael H.
dc.contributor.authorFaulkes, Chris G.
dc.contributor.authorFrankel, Daniel
dc.contributor.authorFriedlander, Gerard
dc.contributor.authorGibney, Patrick A.
dc.contributor.authorGorbunova, Vera
dc.contributor.authorHine, Christopher
dc.contributor.authorHolmes, Melissa M.
dc.contributor.authorJarvis, Jennifer U. M.
dc.contributor.authorKawamura, Yoshimi
dc.contributor.authorKutsukake, Nobuyuki
dc.contributor.authorKenyon, Cynthia
dc.contributor.authorKhaled, Walid T.
dc.contributor.authorKikusui, Takefumi
dc.contributor.authorKissil, Joseph
dc.contributor.authorLagestee, Samantha
dc.contributor.authorLarson, John
dc.contributor.authorLauer, Amanda
dc.contributor.authorLavrenchenko, Leonid A.
dc.contributor.authorLee, Angela
dc.contributor.authorLevitt, Jonathan B.
dc.contributor.authorLewin, Gary R.
dc.contributor.authorLewis Hardell, Kaitlyn N.
dc.contributor.authorLin, TzuHua D.
dc.contributor.authorMason, Matthew J.
dc.contributor.authorMcCloskey, Dan
dc.contributor.authorMcMahon, Mary
dc.contributor.authorMiura, Kyoko
dc.contributor.authorMogi, Kazutaka
dc.contributor.authorNarayan, Vikram
dc.contributor.authorO'Connor, Timothy P.
dc.contributor.authorOkanoya, Kazuo
dc.contributor.authorO'Riain, M. Justin
dc.contributor.authorPark, Thomas J.
dc.contributor.authorPlace, Ned J.
dc.contributor.authorPodshivalova, Katie
dc.contributor.authorPamenter, Matthew E.
dc.contributor.authorPyott, Sonja J.
dc.contributor.authorReznick, Jane
dc.contributor.authorRuby, J. Graham
dc.contributor.authorSalmon, Adam B.
dc.contributor.authorSantos‐Sacchi, Joseph
dc.contributor.authorSarko, Diana K.
dc.contributor.authorSeluanov, Andrei
dc.contributor.authorShepard, Alyssa
dc.contributor.authorSmith, Megan
dc.contributor.authorStorey, Kenneth B.
dc.contributor.authorTian, Xiao
dc.contributor.authorVice, Emily N.
dc.contributor.authorViltard, Mélanie
dc.contributor.authorWatarai, Akiyuki
dc.contributor.authorWywial, Ewa
dc.contributor.authorYamakawa, Masanori
dc.contributor.authorZemlemerova, Elena D.
dc.contributor.authorZions, Michael
dc.contributor.authorSmith, Ewan St. John
dc.date.accessioned2021-09-03T09:08:38Z
dc.date.available2021-09-03T09:08:38Z
dc.date.issued2021-09-03
dc.date.submitted2021-02-15
dc.identifier.issn1464-7931
dc.identifier.issn1469-185X
dc.identifier.otherbrv12791
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/327561
dc.descriptionFunder: Calico Life Sciences, LLC
dc.description.abstractABSTRACT: The naked mole‐rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. It has also generated considerable biomedical interest not only because of its extraordinary longevity, but also because of unusual protective features (e.g. its tolerance of variable oxygen availability), which may be pertinent to several human disease states, including ischemia/reperfusion injury and neurodegeneration. A recent article entitled ‘Surprisingly long survival of premature conclusions about naked mole‐rat biology’ described 28 ‘myths’ which, those authors claimed, are a ‘perpetuation of beautiful, but falsified, hypotheses’ and impede our understanding of this enigmatic mammal. Here, we re‐examine each of these ‘myths’ based on evidence published in the scientific literature. Following Braude et al., we argue that these ‘myths’ fall into four main categories: (i) ‘myths’ that would be better described as oversimplifications, some of which persist solely in the popular press; (ii) ‘myths’ that are based on incomplete understanding, where more evidence is clearly needed; (iii) ‘myths’ where the accumulation of evidence over the years has led to a revision in interpretation, but where there is no significant disagreement among scientists currently working in the field; ( iv ) ‘myths’ where there is a genuine difference in opinion among active researchers, based on alternative interpretations of the available evidence. The term ‘myth’ is particularly inappropriate when applied to competing, evidence‐based hypotheses, which form part of the normal evolution of scientific knowledge. Here, we provide a comprehensive critical review of naked mole‐rat biology and attempt to clarify some of these misconceptions.
dc.languageen
dc.publisherBlackwell Publishing Ltd
dc.subjectOriginal Article
dc.subjectOriginal Articles
dc.subjectnaked mole‐rat
dc.subjectlongevity
dc.subjecthypoxia
dc.subjectcancer
dc.subjectnociception
dc.subjecteusociality
dc.subjectthermoregulation
dc.subjectageing
dc.subjectecology
dc.titleThe naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology
dc.typeArticle
dc.date.updated2021-09-03T09:08:37Z
prism.publicationNameBiological Reviews
dc.identifier.doi10.17863/CAM.75015
dcterms.dateAccepted2021-08-18
rioxxterms.versionofrecord10.1111/brv.12791
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidKawamura, Yoshimi [0000-0002-9864-7974]
dc.contributor.orcidLagestee, Samantha [0000-0001-9412-6859]
dc.contributor.orcidLewin, Gary R. [0000-0002-2890-6352]
dc.contributor.orcidMason, Matthew J. [0000-0001-7845-0720]
dc.contributor.orcidNarayan, Vikram [0000-0002-6128-7944]
dc.contributor.orcidPark, Thomas J. [0000-0002-2447-2948]
dc.contributor.orcidSmith, Ewan St. John [0000-0002-2699-1979]
pubs.funder-project-idDunhill Medical Trust (RPGF2002\188)


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