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dc.contributor.authorRitson, Dougal J
dc.date.accessioned2021-09-15T00:44:14Z
dc.date.available2021-09-15T00:44:14Z
dc.date.issued2021-08
dc.identifier.issn2375-2548
dc.identifier.other34389542
dc.identifier.otherPMC8363140
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/328038
dc.description.abstractThe centrality of the Krebs cycle in metabolism has long been interpreted as evidence of its antiquity, and consequently, questions regarding its provenance, and whether it initially functioned as a cycle or not, have received much attention. The present report shows that prebiotic oxidation of α-hydroxy carboxylates can be achieved by UV photolysis of a simple geochemical species (HS-), which leads to α-oxo carboxylates that feature in the Krebs cycle and glyoxylate shunt. Further reaction of these products leads to almost all intermediates of the Krebs cycle proper, succinate semialdehyde bypass, and glyoxylate shunt. Fumarate, the missing Krebs cycle component, and the required α-hydroxy carboxylates can be provided by a highly related hydrogen cyanide chemistry, which also provides precursors for amino acids, nucleotides, and phospholipids.
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2375-2548
dc.sourcenlmid: 101653440
dc.titleA cyanosulfidic origin of the Krebs cycle.
dc.typeArticle
dc.date.updated2021-09-15T00:44:13Z
prism.issueIdentifier33
prism.publicationNameSci Adv
prism.volume7
dc.identifier.doi10.17863/CAM.75489
dcterms.dateAccepted2021-06-25
rioxxterms.versionofrecord10.1126/sciadv.abh3981
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidRitson, Dougal J [0000-0002-0517-2747]
dc.identifier.eissn2375-2548


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International