Show simple item record

dc.contributor.authorJarvis, Lorna B.
dc.contributor.authorRainbow, Daniel B.
dc.contributor.authorCoppard, Valerie
dc.contributor.authorHowlett, Sarah K.
dc.contributor.authorGeorgieva, Zoya
dc.contributor.authorDavies, Jessica L.
dc.contributor.authorMullay, Harpreet Kaur
dc.contributor.authorHester, Joanna
dc.contributor.authorAshmore, Tom
dc.contributor.authorVan Den Bosch, Aletta
dc.contributor.authorGrist, James T.
dc.contributor.authorColes, Alasdair J.
dc.contributor.authorMousa, Hani S.
dc.contributor.authorPluchino, Stefano
dc.contributor.authorMahbubani, Krishnaa T.
dc.contributor.authorGriffin, Julian L.
dc.contributor.authorSaeb-Parsy, Kourosh
dc.contributor.authorIssa, Fadi
dc.contributor.authorPeruzzotti-Jametti, Luca
dc.contributor.authorWicker, Linda S.
dc.contributor.authorJones, Joanne L.
dc.date.accessioned2021-10-18T08:41:32Z
dc.date.available2021-10-18T08:41:32Z
dc.date.issued2021-10-14
dc.date.submitted2020-11-17
dc.identifier.others42003-021-02721-x
dc.identifier.other2721
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329476
dc.description.abstractAbstract: The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A) driven acquisition of CD73 expression. In conjunction with CD39, CD73 expression enables expanded Tregs to convert ATP to immunosuppressive adenosine. We conclude that for maximum therapeutic benefit, Treg expansion protocols should be optimised for CD39/CD73 co-expression.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/631/250/24/1529
dc.subject/631/250/24/1313
dc.subject/631/250/1619/554/1898/1271
dc.subject/631/250/251/1574
dc.subject/13/1
dc.subject/13/31
dc.subject/13/106
dc.subject/38/39
dc.subject/82
dc.subject/82/58
dc.subject/64/60
dc.subject/13/21
dc.subjectarticle
dc.titleTherapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
dc.typeArticle
dc.date.updated2021-10-18T08:41:31Z
prism.issueIdentifier1
prism.publicationNameCommunications Biology
prism.volume4
dc.identifier.doi10.17863/CAM.76924
dcterms.dateAccepted2021-09-27
rioxxterms.versionofrecord10.1038/s42003-021-02721-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidJarvis, Lorna B. [0000-0002-5760-0125]
dc.contributor.orcidRainbow, Daniel B. [0000-0003-4931-3289]
dc.contributor.orcidDavies, Jessica L. [0000-0002-8888-1441]
dc.contributor.orcidHester, Joanna [0000-0002-7466-3849]
dc.contributor.orcidPluchino, Stefano [0000-0002-6267-9472]
dc.contributor.orcidMahbubani, Krishnaa T. [0000-0002-1327-2334]
dc.contributor.orcidGriffin, Julian L. [0000-0003-1336-7744]
dc.contributor.orcidSaeb-Parsy, Kourosh [0000-0002-0633-3696]
dc.contributor.orcidIssa, Fadi [0000-0002-8279-7732]
dc.contributor.orcidWicker, Linda S. [0000-0001-7771-0324]
dc.contributor.orcidJones, Joanne L. [0000-0003-4974-1371]
dc.identifier.eissn2399-3642
pubs.funder-project-idWellcome Trust (Wellcome) (RG79413)


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record