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dc.contributor.authorLoos, Ruth JF
dc.contributor.authorYeo, Giles
dc.date.accessioned2021-10-26T00:45:57Z
dc.date.available2021-10-26T00:45:57Z
dc.date.issued2022-02
dc.identifier.issn1471-0056
dc.identifier.otherPMC8459824
dc.identifier.other34556834
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329892
dc.description.abstractThe prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.sourceessn: 1471-0064
dc.sourcenlmid: 100962779
dc.titleThe genetics of obesity: from discovery to biology.
dc.typeArticle
dc.date.updated2021-10-26T00:45:56Z
prism.publicationNameNat Rev Genet
dc.identifier.doi10.17863/CAM.77337
dcterms.dateAccepted2021-08-17
rioxxterms.versionofrecord10.1038/s41576-021-00414-z
rioxxterms.versionVoR
dc.contributor.orcidLoos, Ruth JF [0000-0002-8532-5087]
dc.contributor.orcidYeo, Giles [0000-0001-8823-3615]
dc.identifier.eissn1471-0064
pubs.funder-project-idMRC (MC_UU_00014/1)
pubs.funder-project-idMedical Research Council (MC_UU_12012/1)
pubs.funder-project-idMedical Research Council (MC_UU_12012/5)
pubs.funder-project-idMRC (MR/S026193/1)
pubs.funder-project-idMRC (MC_UU_00014/5)
cam.issuedOnline2021-09-23


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