Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity.
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Authors
Belcastro, Livia
Ferreira, Carolina S
Saraiva, Marcelle A
Mucci, Daniela B
Murgia, Antonio
Lai, Carla
Galano, Jean-Marie
Pinto, Gabriela DA
Griffin, Julian L
Durand, Thierry
Burton, Graham J
Sardinha, Fátima LC
Publication Date
2021-08-12Journal Title
Nutrients
ISSN
2072-6643
Publisher
MDPI AG
Volume
13
Issue
8
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Belcastro, L., Ferreira, C. S., Saraiva, M. A., Mucci, D. B., Murgia, A., Lai, C., Vigor, C., et al. (2021). Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity.. Nutrients, 13 (8) https://doi.org/10.3390/nu13082768
Abstract
The rise in prevalence of obesity in women of reproductive age in developed and developing countries might propagate intergenerational cycles of detrimental effects on metabolic health. Placental lipid metabolism is disrupted by maternal obesity, which possibly affects the life-long health of the offspring. Here, we investigated placental lipid metabolism in women with pre-gestational obesity as a sole pregnancy complication and compared it to placental responses of lean women. Open profile and targeted lipidomics were used to assess placental lipids and oxidised products of docosahexaenoic (DHA) and arachidonic acid (AA), respectively, neuroprostanes and isoprostanes. Despite no overall signs of lipid accumulation, DHA and AA levels in placentas from obese women were, respectively, 2.2 and 2.5 times higher than those from lean women. Additionally, a 2-fold increase in DHA-derived neuroprostanes and a 1.7-fold increase in AA-derived isoprostanes were seen in the obese group. These changes correlated with a 70% decrease in placental FABP1 protein. Multivariate analyses suggested that neuroprostanes and isoprostanes are associated with maternal and placental inflammation and with birth weight. These results might shed light on the molecular mechanisms associated with altered placental fatty acid metabolism in maternal pre-gestational obesity, placing these oxidised fatty acids as novel mediators of placental function.
Keywords
arachidonic acid, docosahexaenoic acid, fatty acid transporter proteins, isoprostanes, isoprostanoids, lipid metabolism, maternal pre-gestational obesity, neuroprostanes, placenta, Adult, Birth Weight, Fatty Acid-Binding Proteins, Female, Humans, Inflammation, Isoprostanes, Lipid Metabolism, Maternal Nutritional Physiological Phenomena, Neuroprostanes, Obesity, Maternal, Placenta, Pregnancy
Sponsorship
Medical Research Council (MR/P011705/1)
Identifiers
External DOI: https://doi.org/10.3390/nu13082768
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329957
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