IonFlow: a galaxy tool for the analysis of ionomics data sets.
dc.contributor.author | Iacovacci, J | |
dc.contributor.author | Lin, W | |
dc.contributor.author | Griffin, JL | |
dc.contributor.author | Glen, RC | |
dc.date.accessioned | 2021-10-28T08:08:28Z | |
dc.date.available | 2021-10-28T08:08:28Z | |
dc.date.issued | 2021-09-25 | |
dc.identifier.issn | 1573-3882 | |
dc.identifier.other | PMC8464566 | |
dc.identifier.other | 34562172 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/329983 | |
dc.description.abstract | INTRODUCTION: Inductively coupled plasma mass spectrometry (ICP-MS) experiments generate complex multi-dimensional data sets that require specialist data analysis tools. OBJECTIVE: Here we describe tools to facilitate analysis of the ionome composed of high-throughput elemental profiling data. METHODS: IonFlow is a Galaxy tool written in R for ionomics data analysis and is freely accessible at https://github.com/wanchanglin/ionflow . It is designed as a pipeline that can process raw data to enable exploration and interpretation using multivariate statistical techniques and network-based algorithms, including principal components analysis, hierarchical clustering, relevance network extraction and analysis, and gene set enrichment analysis. RESULTS AND CONCLUSION: The pipeline is described and tested on two benchmark data sets of the haploid S. Cerevisiae ionome and of the human HeLa cell ionome. | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | essn: 1573-3890 | |
dc.source | nlmid: 101274889 | |
dc.subject | Network Biology | |
dc.subject | Ionomics | |
dc.subject | Galaxy Platform | |
dc.title | IonFlow: a galaxy tool for the analysis of ionomics data sets. | |
dc.type | Article | |
dc.date.updated | 2021-10-28T08:08:27Z | |
prism.issueIdentifier | 10 | |
prism.publicationName | Metabolomics | |
prism.volume | 17 | |
dc.identifier.doi | 10.17863/CAM.77427 | |
dcterms.dateAccepted | 2021-09-13 | |
rioxxterms.versionofrecord | 10.1007/s11306-021-01841-z | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.contributor.orcid | Iacovacci, J [0000-0002-1430-5062] | |
dc.identifier.eissn | 1573-3890 | |
pubs.funder-project-id | Wellcome Trust (202952/D/16/Z) | |
cam.issuedOnline | 2021-09-25 |
Files in this item
This item appears in the following Collection(s)
-
Jisc Publications Router
This collection holds Cambridge publications received from the Jisc Publications Router