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dc.contributor.authorGuardia, Tiago
dc.contributor.authorGeerligs, Linda
dc.contributor.authorTsvetanov, Kamen A.
dc.contributor.authorYe, Rong
dc.contributor.authorCampbell, Karen L.
dc.date.accessioned2021-10-29T13:15:38Z
dc.date.available2021-10-29T13:15:38Z
dc.date.issued2021-10-29
dc.date.submitted2021-05-20
dc.identifier.issn1065-9471
dc.identifier.issn1097-0193
dc.identifier.otherhbm25701
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330038
dc.descriptionFunder: Canada Research Chairs program
dc.descriptionFunder: China Scholarship Council; Id: http://dx.doi.org/10.13039/501100004543
dc.descriptionFunder: Ontario Trillium Scholarship
dc.description.abstractAbstract: A common finding in the aging literature is that of the brain's decreased within‐ and increased between‐network functional connectivity. However, it remains unclear what is causing this shift in network organization with age. Given the essential role of the ascending arousal system (ARAS) in cortical activation and previous findings of disrupted ARAS functioning with age, it is possible that age differences in ARAS functioning contribute to disrupted cortical connectivity. We test this possibility here using resting state fMRI data from over 500 individuals across the lifespan from the Cambridge Center for Aging and Neuroscience (Cam‐CAN) population‐based cohort. Our results show that ARAS‐cortical connectivity declines with age and, consistent with our expectations, significantly mediates some age‐related differences in connectivity within and between association networks (specifically, within the default mode and between the default mode and salience networks). Additionally, connectivity between the ARAS and association networks predicted cognitive performance across several tasks over and above the effects of age and connectivity within the cortical networks themselves. These findings suggest that age differences in cortical connectivity may be driven, at least in part, by altered arousal signals from the brainstem and that ARAS–cortical connectivity relates to cognitive performance with age.
dc.languageen
dc.publisherJohn Wiley & Sons, Inc.
dc.subjectRESEARCH ARTICLE
dc.subjectRESEARCH ARTICLES
dc.subjectascending arousal system
dc.subjectfMRI
dc.subjectfunctional networks
dc.subjectneurocognitive aging
dc.titleThe role of the arousal system in age‐related differences in cortical functional network architecture
dc.typeArticle
dc.date.updated2021-10-29T13:15:37Z
prism.publicationNameHuman Brain Mapping
dc.identifier.doi10.17863/CAM.77482
dcterms.dateAccepted2021-10-17
rioxxterms.versionofrecord10.1002/hbm.25701
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidGuardia, Tiago [0000-0003-4517-1922]
dc.contributor.orcidGeerligs, Linda [0000-0002-1624-8380]
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (B/H008217/1)
pubs.funder-project-idBritish Academy Postdoctoral Fellowship (PF160048)
pubs.funder-project-idGuarantors of Brain (G101149)
pubs.funder-project-idNatural Sciences and Engineering Research Council of Canada (RGPIN‐2017‐03804)


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