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dc.contributor.authorEriksen, Anne Marie Høier
dc.contributor.authorNielsen, Tue Kjærgaard
dc.contributor.authorMatthiesen, Henning
dc.contributor.authorCarøe, Christian
dc.contributor.authorHansen, Lars Hestbjerg
dc.contributor.authorGregory, David John
dc.contributor.authorTurner-Walker, Gordon
dc.contributor.authorCollins, Matthew
dc.contributor.authorGilbert, M Thomas P
dc.date.accessioned2021-10-29T23:30:57Z
dc.date.available2021-10-29T23:30:57Z
dc.date.issued2020
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330064
dc.description.abstractBacteria play an important role in the degradation of bone material. However, much remains to be learnt about the structure of their communities in degrading bone, and how the depositional environment influences their diversity throughout the exposure period. We genetically profiled the bacterial community in an experimental series of pig bone fragments (femur and humeri) deposited at different well-defined environments in Denmark. The bacterial community in the bone fragments and surrounding depositional environment were studied over one year, and correlated with the bioerosion damage patterns observed microscopically in the bones. We observed that the bacterial communities within the bones were heavily influenced by the local microbial community, and that the general bone microbial diversity increases with time after exposure. We found the presence of several known collagenase producing bacterial groups, and also observed increases in the relative abundance of several of these in bones with tunneling. We anticipate that future analyses using shotgun metagenomics on this and similar datasets will be able to provide insights into mechanisms of microbiome driven bone degradation.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBone and Bones
dc.subjectAnimals
dc.subjectSwine
dc.subjectBacteria
dc.subjectRNA, Ribosomal, 16S
dc.subjectEnvironmental Exposure
dc.subjectPhylogeny
dc.subjectMicrobiota
dc.titleBone biodeterioration-The effect of marine and terrestrial depositional environments on early diagenesis and bone bacterial community.
dc.typeArticle
prism.issueIdentifier10
prism.publicationDate2020
prism.publicationNamePLoS One
prism.startingPagee0240512
prism.volume15
dc.identifier.doi10.17863/CAM.77508
dcterms.dateAccepted2020-09-29
rioxxterms.versionofrecord10.1371/journal.pone.0240512
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-01
dc.contributor.orcidEriksen, Anne Marie Høier [0000-0001-5243-5207]
dc.contributor.orcidNielsen, Tue Kjærgaard [0000-0001-6610-8450]
dc.contributor.orcidCollins, Matthew [0000-0003-4226-5501]
dc.identifier.eissn1932-6203
rioxxterms.typeJournal Article/Review
cam.issuedOnline2020-10-15


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International