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dc.contributor.authorPerrone, Francesca
dc.contributor.authorZilbauer, Matthias
dc.date.accessioned2021-11-04T16:21:45Z
dc.date.available2021-11-04T16:21:45Z
dc.date.issued2021-10
dc.date.submitted2020-11-26
dc.identifier.issn1226-3613
dc.identifier.others12276-021-00606-x
dc.identifier.other606
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330290
dc.descriptionFunder: MRC New Investigator Research Grant (MZ) European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)
dc.description.abstractThe development of human organoid culture models has led to unprecedented opportunities to generate self-organizing, three-dimensional miniature organs that closely mimic in vivo conditions. The ability to expand, culture, and bank such organoids now provide researchers with the opportunity to generate next-generation living biobanks, which will substantially contribute to translational research in a wide range of areas, including drug discovery and testing, regenerative medicine as well as the development of a personalized treatment approach. However, compared to traditional tissue repositories, the generation of a living organoid biobank requires a much higher level of coordination, additional resources, and scientific expertise. In this short review, we discuss the opportunities and challenges associated with the generation of a living organoid biobank. Focusing on human intestinal organoids, we highlight some of the key aspects that need to be considered and provide an outlook for future development in this exciting field.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectReview Article
dc.subject/692/308/575
dc.subject/631/532/2437
dc.subjectreview-article
dc.titleBiobanking of human gut organoids for translational research.
dc.typeArticle
dc.date.updated2021-11-04T16:21:44Z
prism.endingPage1458
prism.issueIdentifier10
prism.publicationNameExp Mol Med
prism.startingPage1451
prism.volume53
dc.identifier.doi10.17863/CAM.77734
dcterms.dateAccepted2021-03-03
rioxxterms.versionofrecord10.1038/s12276-021-00606-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidZilbauer, Matthias [0000-0002-7272-0547]
dc.identifier.eissn2092-6413
cam.issuedOnline2021-10-18


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