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dc.contributor.authorNí Leathlobhair, Máire
dc.contributor.authorYetsko, Kelsey
dc.contributor.authorFarrell, Jessica A
dc.contributor.authorIaria, Carmelo
dc.contributor.authorMarino, Gabriele
dc.contributor.authorDuffy, David J
dc.contributor.authorMurchison, Elizabeth P
dc.date.accessioned2021-11-09T01:59:22Z
dc.date.available2021-11-09T01:59:22Z
dc.date.issued2021-09-02
dc.identifier.issn2398-502X
dc.identifier.otherPMC8459624
dc.identifier.other34622016
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330485
dc.description.abstractRecent discoveries of transmissible cancers in multiple bivalve species suggest that direct transmission of cancer cells within species may be more common than previously thought, particularly in aquatic environments. Fibropapillomatosis occurs with high prevalence in green sea turtles ( <i>Chelonia mydas</i>) and the geographic range of disease has increased since fibropapillomatosis was first reported in this species. Widespread incidence of schwannomas, benign tumours of Schwann cell origin, reported in aquarium-bred goldfish <i>(Carassius auratus),</i> suggest an infectious aetiology. We investigated the hypothesis that cancers in these species arise by clonal transmission of cancer cells. Through analysis of polymorphic microsatellite alleles, we demonstrate concordance of host and tumour genotypes in diseased animals. These results imply that the tumours examined arose from independent oncogenic transformation of host tissue and were not clonally transmitted. Further, failure to experimentally transmit goldfish schwannoma via water exposure or inoculation suggest that this disease is unlikely to have an infectious aetiology.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2398-502X
dc.sourcenlmid: 101696457
dc.subjectTransmissible Cancer
dc.subjectFibropapillomatosis
dc.subjectWildlife Cancer
dc.subjectGoldfish Schwannoma
dc.subjectSea Turtle Fibropapillomatosis
dc.titleGenotype data not consistent with clonal transmission of sea turtle fibropapillomatosis or goldfish schwannoma.
dc.typeArticle
dc.date.updated2021-11-09T01:59:21Z
prism.publicationNameWellcome open research
prism.volume6
dc.identifier.doi10.17863/CAM.77929
rioxxterms.versionofrecord10.12688/wellcomeopenres.17073.1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidNí Leathlobhair, Máire [0000-0002-8523-4935]
dc.contributor.orcidIaria, Carmelo [0000-0001-7930-8881]
dc.contributor.orcidDuffy, David J [0000-0002-6075-8855]
dc.contributor.orcidMurchison, Elizabeth P [0000-0001-7462-8907]
pubs.funder-project-idWellcome Trust (102942)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International