The role of GDF15 in food intake and appetitive behaviour
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Publication Date
2022-02Journal Title
Current Opinion in Endocrine and Metabolic Research
ISSN
2451-9650
Publisher
Elsevier BV
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Cimino, I., & Coll, A. (2022). The role of GDF15 in food intake and appetitive behaviour. Current Opinion in Endocrine and Metabolic Research https://doi.org/10.1016/j.coemr.2021.100299
Abstract
The peptide hormone GDF15 is a potent anorectic factor. Raised circulating levels of GDF15 are seen in a large number of pathological disorders and are associated invariably with adverse clinical outcomes. GDF15 signalling is mediated through GFRAL receptor in the hindbrain. A greater understanding of the mechanisms that drive expression of GDF15 within different tissues has led to the GDF15-GFRAL axis being considered a route through which somatic distress is signalled to the brain. We highlight key recent insights into the role of GDF15 in appetitive behaviour and reflect on the therapeutic potential of the system for disorders of energy balance.
Keywords
1 Underpinning research, 1.1 Normal biological development and functioning, Cancer, Cardiovascular, Metabolic and endocrine, Neurological, Mental health
Sponsorship
UK Medical Research Council (MRC) Metabolic Diseases Unit (MRC_MC_UU_12012/1 and MC_UU_00014/1)
Funder references
MRC (MC_UU_00014/1)
Medical Research Council (MC_UU_12012/1)
Medical Research Council (MC_PC_12012)
Identifiers
External DOI: https://doi.org/10.1016/j.coemr.2021.100299
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330700
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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