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dc.contributor.authorSovio, Ulla
dc.contributor.authorGoulding, Neil
dc.contributor.authorMcBride, Nancy
dc.contributor.authorCook, Emma
dc.contributor.authorGaccioli, Francesca
dc.contributor.authorCharnock-Jones, D Stephen
dc.contributor.authorLawlor, Deborah A
dc.contributor.authorSmith, Gordon CS
dc.date.accessioned2021-11-18T00:30:22Z
dc.date.available2021-11-18T00:30:22Z
dc.date.issued2022-03-24
dc.identifier.issn0021-972X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330721
dc.description.abstractCONTEXT: Excessive birth weight is associated with maternal and neonatal complications. However, ultrasonically estimated large for gestational age (LGA; >90th percentile) predicts these complications poorly. OBJECTIVE: To determine whether a maternal serum metabolite ratio developed for fetal growth restriction (FGR) is predictive of birth weight across the whole range, including LGA at birth. METHODS: Metabolites were measured using ultrahigh performance liquid chromatography-tandem mass spectroscopy. The 4-metabolite ratio was previously derived from an analysis of FGR cases and a random subcohort from the Pregnancy Outcome Prediction study. Here, we evaluated its relationship at 36 weeks of gestational age (wkGA) with birth weight in the subcohort (n = 281). External validation in the Born in Bradford (BiB) study (n = 2366) used the metabolite ratio at 24 to 28 wkGA. RESULTS: The inverse of the metabolite ratio at 36 wkGA predicted LGA at term [the area under the receiver operating characteristic curve (AUROCC) = 0.82, 95% CI 0.73 to 0.91, P = 6.7 × 10-5]. The ratio was also inversely associated with birth weight z score (linear regression, beta = -0.29 SD, P = 2.1 × 10-8). Analysis in the BiB cohort confirmed that the ratio at 24 to 28 wkGA predicted LGA (AUROCC = 0.60, 95% CI 0.54 to 0.67, P = 8.6 × 10-5) and was inversely associated with birth weight z score (beta = -0.12 SD, P = 1.3 × 10-9). CONCLUSIONS: A metabolite ratio which is strongly predictive of FGR is equally predictive of LGA birth weight and is inversely associated with birth weight across the whole range.
dc.description.sponsorshipThe work was supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (Women’s Health theme), the Medical Research Council (United Kingdom; 1100221 to G.C.S.S. and D.S.C.-J., MR/N024397/1 to D.A.L.), the Wellcome Trust (WT101597MA), National Institutes of Health (R01 DK10324), the European Research Council (669545), and the NIHR Biomedical Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol (Reproductive and Perinatal Health theme), which funds N.M.’s PhD studentship. N.G., N.M. and D.A.L. work in a unit that receives support from the MRC (MC_UU_00011/6) and University of Bristol. D.A.L. is an NIHR Senior Investigator (NF-SI-0611-10196).
dc.publisherThe Endocrine Society
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjectPregnancy
dc.subjectMetabolomics
dc.subjectLarge for gestational age
dc.subjectMacrosomia
dc.subjectPrediction
dc.titleA Maternal Serum Metabolite Ratio Predicts Large for Gestational Age Infants at Term: A Prospective Cohort Study.
dc.typeArticle
prism.publicationNameJ Clin Endocrinol Metab
dc.identifier.doi10.17863/CAM.78164
dcterms.dateAccepted2021-11-15
rioxxterms.versionofrecord10.1210/clinem/dgab842
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-11-15
dc.contributor.orcidSovio, Ulla [0000-0002-0799-1105]
dc.contributor.orcidGoulding, Neil [0000-0002-2488-4598]
dc.contributor.orcidMcBride, Nancy [0000-0003-4439-4710]
dc.contributor.orcidCook, Emma [0000-0002-6142-4443]
dc.contributor.orcidGaccioli, Francesca [0000-0001-7178-8921]
dc.contributor.orcidCharnock-Jones, D Stephen [0000-0002-2936-4890]
dc.contributor.orcidLawlor, Deborah A [0000-0002-6793-2262]
dc.contributor.orcidSmith, Gordon CS [0000-0003-2124-0997]
dc.identifier.eissn1945-7197
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMedical Research Council (G1100221)
cam.issuedOnline2021-11-19
datacite.issupplementedby.doi10.17863/CAM.76865
cam.orpheus.successTue Feb 01 19:02:17 GMT 2022 - Embargo updated
cam.orpheus.counter1
rioxxterms.freetoread.startdate2022-11-19


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