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dc.contributor.authorMurley, Alexander
dc.contributor.authorTsvetanov, Kamen A.
dc.contributor.authorRouse, Matthew
dc.contributor.authorJones, Simon
dc.contributor.authorSværke, Katrine
dc.contributor.authorLi, Win
dc.contributor.authorCarpenter, Adrian
dc.contributor.authorRowe, James
dc.date.accessioned2021-11-20T00:30:07Z
dc.date.available2021-11-20T00:30:07Z
dc.date.issued2022-03
dc.identifier.issn0197-4580
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330760
dc.description.abstractThere is an urgent need for a better understanding of the pathophysiology of cognitive impairment in syndromes associated with frontotemporal lobar degeneration. Here, we used magnetic resonance spectroscopy to quantify metabolite deficits in sixty patients with a clinical syndrome associated with frontotemporal lobar degeneration (behavioral variant frontotemporal dementia n = 11, progressive supranuclear palsy n = 26, corticobasal syndrome n = 11, primary progressive aphasias n = 12), and 38 age- and sex-matched healthy controls. We measured nine metabolites in the right inferior frontal gyrus, superior temporal gyrus and right primary visual cortex. Metabolite concentrations were corrected for age, sex, and partial volume then compared with cognitive and behavioral measures using canonical correlation analysis. Metabolite concentrations varied significantly by brain region and diagnosis (region x metabolite x diagnosis interaction F(64) = 1.73, p < 0.001, corrected for age, sex, and atrophy within the voxel). N-acetyl aspartate and glutamate concentrations were reduced in the right prefrontal cortex in behavioral variant frontotemporal dementia and progressive supranuclear palsy, even after partial volume correction. The reduction of these metabolites was associated with executive dysfunction and behavioral impairment (canonical correlation analysis R = 0.85, p < 0.001).
dc.languageen
dc.publisherElsevier BV
dc.rightsAll rights reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleProton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.
dc.typeArticle
prism.publicationDate2021
prism.publicationNameNeurobiol Aging
dc.identifier.doi10.17863/CAM.78201
dcterms.dateAccepted2021-10-23
rioxxterms.versionofrecord10.1016/j.neurobiolaging.2021.10.012
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-10
dc.contributor.orcidMurley, Alexander [0000-0003-0813-0670]
dc.contributor.orcidTsvetanov, Kamen A. [0000-0002-3178-6363]
dc.contributor.orcidRouse, Matthew [0000-0002-3157-4301]
dc.contributor.orcidJones, Simon [0000-0001-9695-0702]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1558-1497
rioxxterms.typeJournal Article/Review
pubs.funder-project-id(unknown)
pubs.funder-project-idWellcome Trust (103838/Z/14/Z)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idBritish Academy (pf160048)
pubs.funder-project-idGuarantors of Brain (Unknown)
pubs.funder-project-idNational Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
pubs.funder-project-idMedical Research Council (MR/M009041/1)
cam.orpheus.success2021-11-19 - Embargo set during processing via Fast-track
rioxxterms.freetoread.startdate2022-10-31


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