jats:titleAbstract</jats:title>jats:pThe flow of high‐temperature and compositionally enriched material between mantle plumes and nearby spreading centers influences up to 30% of the global mid‐ocean ridge system and represents a significant, but currently unconstrained, flux of volatiles out of the mantle. Here, we present new analyses of Hjats:sub2</jats:sub>O, F, Cl, and S in basaltic glass chips from an archetypal region of plume‐ridge interaction, the Galápagos Spreading Center (GSC). Our data set includes samples from the eastern GSC, on ridge segments that are strongly influenced by the adjacent Galápagos mantle plume, and complements published analyses of volatiles largely from the western GSC. We use forward models of mantle melting to investigate the role of solid and melt‐phase transport from a lithologically heterogeneous (peridotite‐pyroxenite) mantle in plume‐ridge interaction along approximately 1,000 km of the GSC. Our results indicate that the observed geochemical and geophysical variations cannot be recreated by models that only involve solid‐state transfer of material between the Galápagos mantle plume and the GSC. Instead, we show that the geochemical and geophysical data from the GSC are well‐matched by models that incorporate channelized flow of volatile‐rich melts formed at high‐pressures (>3 GPa) in the Galápagos plume stem to the GSC. In addition, our new models demonstrate that channelized flow of enriched, plume‐derived melt can account for up to ∼60% of the Hjats:sub2</jats:sub>O outgassed from regions of the GSC, which are most strongly influenced by the Galápagos mantle plume.</jats:p>