jats:pIt is the tradition for the fluid community to study fluid dynamics problems via numerical simulations such as finite-element, finite-difference and finite-volume methods. These approaches use various mesh techniques to discretize a complicated geometry and eventually convert governing equations into finite-dimensional algebraic systems. To date, many attempts have been made by exploiting machine learning to solve flow problems. However, conventional data-driven machine learning algorithms require heavy inputs of large labeled data, which is computationally expensive for complex and multi-physics problems. In this paper, we proposed a data-free, physics-driven deep learning approach to solve various low-speed flow problems and demonstrated its robustness in generating reliable solutions. Instead of feeding neural networks large labeled data, we exploited the known physical laws and incorporated this physics into a neural network to relax the strict requirement of big data and improve prediction accuracy. The employed physics-informed neural networks (PINNs) provide a feasible and cheap alternative to approximate the solution of differential equations with specified initial and boundary conditions. Approximate solutions of physical equations can be obtained via the minimization of the customized objective function, which consists of residuals satisfying differential operators, the initial/boundary conditions as well as the mean-squared errors between predictions and target values. This new approach is data efficient and can greatly lower the computational cost for large and complex geometries. The capacity and generality of the proposed method have been assessed by solving various flow and transport problems, including the flow past cylinder, linear Poisson, heat conduction and the Taylor–Green vortex problem.</jats:p>