RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients.
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Authors
RA-MAP Consortium
Publication Date
2022-05-09Journal Title
Sci Data
ISSN
2052-4463
Publisher
Springer Science and Business Media LLC
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
RA-MAP Consortium. (2022). RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients.. Sci Data https://doi.org/10.1038/s41597-022-01264-y
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets. We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profiling. We anticipate that these detailed clinical and molecular data will serve as a fundamental resource offering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA.
Keywords
Arthritis, Rheumatoid, Autoantibodies, Biological Specimen Banks, Humans, Monocytes, Proteomics, Vaccines
Sponsorship
Medical Research Council, 415 UK (An Immunological Toolkit for Clinical Application, grant number G1001518)
Funder references
Medical Research Council (MR/L016311/1)
Identifiers
External DOI: https://doi.org/10.1038/s41597-022-01264-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331006
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