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dc.contributor.authorBurden-Teh, E
dc.contributor.authorMurphy, R
dc.contributor.authorGran, S
dc.contributor.authorNijsten, T
dc.contributor.authorHughes, C
dc.contributor.authorAbdul-Wahab, A
dc.contributor.authorBewley, A
dc.contributor.authorBurrows, N
dc.contributor.authorDarne, S
dc.contributor.authorGach, JE
dc.contributor.authorKatugampola, R
dc.contributor.authorJury, CS
dc.contributor.authorKuet, K
dc.contributor.authorLlewellyn, J
dc.contributor.authorMcPherson, T
dc.contributor.authorRavenscroft, JC
dc.contributor.authorTaibjee, S
dc.contributor.authorWilkinson, C
dc.contributor.authorThomas, KS
dc.date.accessioned2021-11-24T15:17:40Z
dc.date.available2021-11-24T15:17:40Z
dc.date.issued2022-02
dc.identifier.issn0007-0963
dc.identifier.otherbjd20689
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331022
dc.description.abstractBACKGROUND: In children, psoriasis can be challenging to diagnose. Difficulties arise from differences in the clinical presentation compared with adults. OBJECTIVES: To test the diagnostic accuracy of previously agreed consensus criteria and to develop a shortlist of the best predictive diagnostic criteria for childhood psoriasis. METHODS: A case-control diagnostic accuracy study in 12 UK dermatology departments (2017-2019) assessed 18 clinical criteria using blinded trained investigators. Children (< 18 years) with dermatologist-diagnosed psoriasis (cases, N = 170) or a different scaly inflammatory rash (controls, N = 160) were recruited. The best predictive criteria were identified using backward logistic regression, and internal validation was conducted using bootstrapping. RESULTS: The sensitivity of the consensus-agreed criteria and consensus scoring algorithm was 84·6%, the specificity was 65·1% and the area under the curve (AUC) was 0·75. The seven diagnostic criteria that performed best were: (i) scale and erythema in the scalp involving the hairline, (ii) scaly erythema inside the external auditory meatus, (iii) persistent well-demarcated erythematous rash anywhere on the body, (iv) persistent erythema in the umbilicus, (v) scaly erythematous plaques on the extensor surfaces of the elbows and/or knees, (vi) well-demarcated erythematous rash in the napkin area involving the crural fold and (vii) family history of psoriasis. The sensitivity of the best predictive model was 76·8%, with specificity 72·7% and AUC 0·84. The c-statistic optimism-adjusted shrinkage factor was 0·012. CONCLUSIONS: This study provides examination- and history-based data on the clinical features of psoriasis in children and proposes seven diagnostic criteria with good discriminatory ability in secondary-care patients. External validation is now needed.
dc.languageen
dc.publisherWiley
dc.subjectPaediatric Dermatology
dc.titleIdentifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case-control diagnostic accuracy study (DIPSOC study).
dc.typeArticle
dc.date.updated2021-11-24T15:17:39Z
prism.publicationNameBr J Dermatol
dc.identifier.doi10.17863/CAM.78467
dcterms.dateAccepted2021-08-05
rioxxterms.versionofrecord10.1111/bjd.20689
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBurden-Teh, E [0000-0002-0033-2836]
dc.contributor.orcidGran, S [0000-0002-2443-5100]
dc.contributor.orcidNijsten, T [0000-0001-9940-2875]
dc.contributor.orcidAbdul-Wahab, A [0000-0002-1474-0398]
dc.contributor.orcidBewley, A [0000-0003-1195-0290]
dc.contributor.orcidBurrows, N [0000-0002-1090-8261]
dc.contributor.orcidDarne, S [0000-0002-6155-7772]
dc.contributor.orcidGach, JE [0000-0002-0333-7165]
dc.contributor.orcidMcPherson, T [0000-0001-9215-0302]
dc.contributor.orcidRavenscroft, JC [0000-0002-1609-7084]
dc.contributor.orcidTaibjee, S [0000-0003-2433-5481]
dc.contributor.orcidThomas, KS [0000-0001-7785-7465]
dc.identifier.eissn1365-2133
pubs.funder-project-idResearch Trainees Coordinating Centre (DRF‐2016‐09‐083)
cam.issuedOnline2021-11-24


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