Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium.
Br J Cancer
Springer Science and Business Media LLC
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Park, J., Dahm, C., Keogh, R., Mitrou, P., Cairns, B., Greenwood, D., Spencer, E., et al. (2010). Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium.. Br J Cancer, 103 (5), 747-756. https://doi.org/10.1038/sj.bjc.6605802
BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent. METHODS: We investigated the prospective associations between alcohol intake on overall and site- and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ). RESULTS: Compared with individuals in the lightest category of drinkers (>0-<5 g per day), the multivariable odds ratios of CRC were 1.16 (95% confidence interval (95% CI): 0.88, 1.53) for non-drinkers, 0.91 (95% CI: 0.67, 1.24) for drinkers with 5-<15 g per day, 0.90 (95% CI: 0.65, 1.25) for drinkers with 15-<30 g per day, 1.02 (95% CI: 0.66, 1.58) for drinkers with 30-<45 g per day and 1.19 (95% CI: 0.75, 1.91) for drinkers with >or=45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results. CONCLUSION: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.
Humans, Colorectal Neoplasms, Diet, Risk Factors, Case-Control Studies, Alcohol Drinking, Smoking, Middle Aged, Female, Male, United Kingdom
Medical Research Council (G0401527)
Medical Research Council (G0500300)
External DOI: https://doi.org/10.1038/sj.bjc.6605802
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331121
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Licence URL: https://creativecommons.org/licenses/by-nc-sa/4.0/