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dc.contributor.authorEl Bairi, Khalid
dc.contributor.authorHaynes, Harry R
dc.contributor.authorBlackley, Elizabeth
dc.contributor.authorFineberg, Susan
dc.contributor.authorShear, Jeffrey
dc.contributor.authorTurner, Sophia
dc.contributor.authorde Freitas, Juliana Ribeiro
dc.contributor.authorSur, Daniel
dc.contributor.authorAmendola, Luis Claudio
dc.contributor.authorGharib, Masoumeh
dc.contributor.authorKallala, Amine
dc.contributor.authorArun, Indu
dc.contributor.authorAzmoudeh-Ardalan, Farid
dc.contributor.authorFujimoto, Luciana
dc.contributor.authorSua, Luz F
dc.contributor.authorLiu, Shi-Wei
dc.contributor.authorLien, Huang-Chun
dc.contributor.authorKirtani, Pawan
dc.contributor.authorBalancin, Marcelo
dc.contributor.authorEl Attar, Hicham
dc.contributor.authorGuleria, Prerna
dc.contributor.authorYang, Wenxian
dc.contributor.authorShash, Emad
dc.contributor.authorChen, I-Chun
dc.contributor.authorBautista, Veronica
dc.contributor.authorDo Prado Moura, Jose Fernando
dc.contributor.authorRapoport, Bernardo L
dc.contributor.authorCastaneda, Carlos
dc.contributor.authorSpengler, Eunice
dc.contributor.authorAcosta-Haab, Gabriela
dc.contributor.authorFrahm, Isabel
dc.contributor.authorSanchez, Joselyn
dc.contributor.authorCastillo, Miluska
dc.contributor.authorBouchmaa, Najat
dc.contributor.authorMd Zin, Reena R
dc.contributor.authorShui, Ruohong
dc.contributor.authorOnyuma, Timothy
dc.contributor.authorYang, Wentao
dc.contributor.authorHusain, Zaheed
dc.contributor.authorWillard-Gallo, Karen
dc.contributor.authorCoosemans, An
dc.contributor.authorPerez, Edith A
dc.contributor.authorProvenzano, Elena
dc.contributor.authorEricsson, Paula Gonzalez
dc.contributor.authorRichardet, Eduardo
dc.contributor.authorMehrotra, Ravi
dc.contributor.authorSarancone, Sandra
dc.contributor.authorEhinger, Anna
dc.contributor.authorRimm, David L
dc.contributor.authorBartlett, John MS
dc.contributor.authorViale, Giuseppe
dc.contributor.authorDenkert, Carsten
dc.contributor.authorHida, Akira I
dc.contributor.authorSotiriou, Christos
dc.contributor.authorLoibl, Sibylle
dc.contributor.authorHewitt, Stephen M
dc.contributor.authorBadve, Sunil
dc.contributor.authorSymmans, William Fraser
dc.contributor.authorKim, Rim S
dc.contributor.authorPruneri, Giancarlo
dc.contributor.authorGoel, Shom
dc.contributor.authorFrancis, Prudence A
dc.contributor.authorInurrigarro, Gloria
dc.contributor.authorYamaguchi, Rin
dc.contributor.authorGarcia-Rivello, Hernan
dc.contributor.authorHorlings, Hugo
dc.contributor.authorAfqir, Said
dc.contributor.authorSalgado, Roberto
dc.contributor.authorAdams, Sylvia
dc.contributor.authorKok, Marleen
dc.contributor.authorDieci, Maria Vittoria
dc.contributor.authorMichiels, Stefan
dc.contributor.authorDemaria, Sandra
dc.contributor.authorLoi, Sherene
dc.contributor.authorInternational Immuno-Oncology Biomarker Working Group
dc.date.accessioned2021-12-15T12:13:40Z
dc.date.available2021-12-15T12:13:40Z
dc.date.issued2021-12-01
dc.date.submitted2020-11-03
dc.identifier.issn2374-4677
dc.identifier.others41523-021-00346-1
dc.identifier.other346
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331501
dc.description.abstractThe advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectReview Article
dc.subject/692/53/2423
dc.subject/692/4028/67/1347
dc.subjectreview-article
dc.titleThe tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group.
dc.typeArticle
dc.date.updated2021-12-15T12:13:39Z
prism.issueIdentifier1
prism.publicationNameNPJ Breast Cancer
prism.volume7
dc.identifier.doi10.17863/CAM.78955
dcterms.dateAccepted2021-09-28
rioxxterms.versionofrecord10.1038/s41523-021-00346-1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidEl Bairi, Khalid [0000-0002-8414-4145]
dc.contributor.orcidde Freitas, Juliana Ribeiro [0000-0003-4978-7273]
dc.contributor.orcidSur, Daniel [0000-0002-0926-4614]
dc.contributor.orcidAmendola, Luis Claudio [0000-0002-6404-450X]
dc.contributor.orcidAzmoudeh-Ardalan, Farid [0000-0003-4701-0532]
dc.contributor.orcidKirtani, Pawan [0000-0002-2343-7016]
dc.contributor.orcidYang, Wenxian [0000-0002-5349-9680]
dc.contributor.orcidCastillo, Miluska [0000-0002-0111-3176]
dc.contributor.orcidProvenzano, Elena [0000-0003-3345-3965]
dc.contributor.orcidMehrotra, Ravi [0000-0001-9453-1408]
dc.contributor.orcidEhinger, Anna [0000-0001-9225-7396]
dc.contributor.orcidRimm, David L [0000-0001-5820-4397]
dc.contributor.orcidBartlett, John MS [0000-0002-0347-3888]
dc.contributor.orcidDenkert, Carsten [0000-0002-2249-0982]
dc.contributor.orcidHida, Akira I [0000-0002-4486-8819]
dc.contributor.orcidSotiriou, Christos [0000-0002-5745-9977]
dc.contributor.orcidHewitt, Stephen M [0000-0001-8283-1788]
dc.contributor.orcidBadve, Sunil [0000-0001-8861-9980]
dc.contributor.orcidSymmans, William Fraser [0000-0002-1526-184X]
dc.contributor.orcidGoel, Shom [0000-0001-8329-9084]
dc.contributor.orcidFrancis, Prudence A [0000-0002-7207-9286]
dc.contributor.orcidHorlings, Hugo [0000-0003-4782-8828]
dc.contributor.orcidSalgado, Roberto [0000-0002-1110-3801]
dc.contributor.orcidDemaria, Sandra [0000-0003-4426-0499]
dc.contributor.orcidLoi, Sherene [0000-0001-6137-9171]
dc.identifier.eissn2374-4677
cam.issuedOnline2021-12-01


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