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dc.contributor.authorLonghitano, Yaroslava
dc.contributor.authorIannuzzi, Francesca
dc.contributor.authorBonatti, Giulia
dc.contributor.authorZanza, Christian
dc.contributor.authorMessina, Antonio
dc.contributor.authorGodoy, Daniel
dc.contributor.authorDabrowski, Wojciech
dc.contributor.authorXiuyun, Li
dc.contributor.authorCzosnyka, Marek
dc.contributor.authorPelosi, Paolo
dc.contributor.authorBadenes, Rafael
dc.contributor.authorRobba, Chiara
dc.date.accessioned2021-12-15T12:14:01Z
dc.date.available2021-12-15T12:14:01Z
dc.date.issued2021-11-16
dc.date.submitted2021-06-28
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331504
dc.description.abstractIntroduction: Cerebral autoregulation (CA) plays a fundamental role in the maintenance of adequate cerebral blood flow (CBF). CA monitoring, through direct and indirect techniques, may guide an appropriate therapeutic approach aimed at improving CBF and reducing neurological complications; so far, the role of CA has been investigated mainly in brain-injured patients. The aim of this study is to investigate the role of CA in non-brain injured patients. Methods: A systematic consultation of literature was carried out. Search terms included: “CA and sepsis,” “CA and surgery,” and “CA and non-brain injury.” Results: Our research individualized 294 studies and after screening, 22 studies were analyzed in this study. Studies were divided in three groups: CA in sepsis and septic shock, CA during surgery, and CA in the pediatric population. Studies in sepsis and intraoperative setting highlighted a relationship between the incidence of sepsis-associated delirium and impaired CA. The most investigated setting in the pediatric population is cardiac surgery, but the role and measurement of CA need to be further elucidated. Conclusion: In non-brain injured patients, impaired CA may result in cognitive dysfunction, neurological damage, worst outcome, and increased mortality. Monitoring CA might be a useful tool for the bedside optimization and individualization of the clinical management in this group of patients.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.subjectNeurology
dc.subjectcerebral autoregulation
dc.subjectnon-brain injury
dc.subjectneurologic outcome
dc.subjectsepsis
dc.subjectperioperative care
dc.subjectpediatric surgery
dc.titleCerebral Autoregulation in Non-Brain Injured Patients: A Systematic Review
dc.typeArticle
dc.date.updated2021-12-15T12:14:00Z
prism.publicationNameFrontiers in Neurology
prism.volume12
dc.identifier.doi10.17863/CAM.78958
dcterms.dateAccepted2021-10-11
rioxxterms.versionofrecord10.3389/fneur.2021.732176
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1664-2295


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