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dc.contributor.authorRoberts, Gemma
dc.contributor.authorLloyd, Jim J
dc.contributor.authorJefferson, Elizabeth
dc.contributor.authorKane, Joseph PM
dc.contributor.authorDurcan, Rory
dc.contributor.authorLawley, Sarah
dc.contributor.authorPetrides, George S
dc.contributor.authorHowe, Kim
dc.contributor.authorHaq, Iftikhar
dc.contributor.authorO'Brien, John T
dc.contributor.authorThomas, Alan J
dc.date.accessioned2021-12-24T13:36:04Z
dc.date.available2021-12-24T13:36:04Z
dc.date.issued2021-10
dc.date.submitted2019-08-24
dc.identifier.issn1071-3581
dc.identifier.others12350-019-01977-5
dc.identifier.other1977
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331791
dc.description.abstractINTRODUCTION: Some studies report that assessing regional 123I-cardiac MIBG uptake can aid in the diagnosis of Lewy body disease, but others report heterogeneity in healthy controls. We aimed to evaluate regional cardiac MIBG uptake patterns in healthy older adults and patients with dementia. METHODS: 31 older adults with normal cognition, 15 Alzheimer's disease (AD), and 17 Dementia with Lewy bodies (DLB) patients were recruited. 5 individuals had previous myocardial infarction. Participants with sufficient cardiac uptake for regional SPECT analysis (29/31 controls, 15/15 AD, 5/17 DLB) had relative uptake pattern recorded. Controls were assessed for risk of future cardiovascular events using QRISK2, a validated online tool. RESULTS: In controls uptake was reduced in the inferior wall (85%), apex (23%), septum (15%), and lateral wall (8%). AD and DLB showed similar patterns to controls. Lung or liver interference was present in 61% of cases. Myocardial infarction cases showed regional reductions in uptake, but normal/borderline planar uptake. In controls, there was no relationship between cardiovascular risk score and uptake pattern. CONCLUSIONS: Significant variability of regional cardiac 123I-MIBG uptake is common in cases with normal planar cardiac uptake. Heterogeneity of regional uptake appears non-specific and unlikely to aid in the diagnosis of Lewy body disease.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectOriginal Article
dc.subjectCardiac MIBG
dc.subjectSPECT
dc.subjectsympathetic innervation
dc.subjectcardiac MIBG uptake homogeneity
dc.subjectSPECT artifacts
dc.titleUniformity of cardiac 123I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia.
dc.typeArticle
dc.date.updated2021-12-24T13:36:04Z
prism.endingPage2163
prism.issueIdentifier5
prism.publicationNameJ Nucl Cardiol
prism.startingPage2151
prism.volume28
dc.identifier.doi10.17863/CAM.79240
dcterms.dateAccepted2019-11-18
rioxxterms.versionofrecord10.1007/s12350-019-01977-5
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1532-6551
cam.issuedOnline2019-12-09


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