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dc.contributor.authorGarcia-Alonso, Luz
dc.contributor.authorHandfield, Louis-François
dc.contributor.authorRoberts, Kenny
dc.contributor.authorNikolakopoulou, Konstantina
dc.contributor.authorFernando, Ridma C
dc.contributor.authorGardner, Lucy
dc.contributor.authorWoodhams, Benjamin
dc.contributor.authorArutyunyan, Anna
dc.contributor.authorPolanski, Krzysztof
dc.contributor.authorHoo, Regina
dc.contributor.authorSancho-Serra, Carmen
dc.contributor.authorLi, Tong
dc.contributor.authorKwakwa, Kwasi
dc.contributor.authorTuck, Elizabeth
dc.contributor.authorLorenzi, Valentina
dc.contributor.authorMassalha, Hassan
dc.contributor.authorPrete, Martin
dc.contributor.authorKleshchevnikov, Vitalii
dc.contributor.authorTarkowska, Aleksandra
dc.contributor.authorPorter, Tarryn
dc.contributor.authorMazzeo, Cecilia Icoresi
dc.contributor.authorvan Dongen, Stijn
dc.contributor.authorDabrowska, Monika
dc.contributor.authorVaskivskyi, Vasyl
dc.contributor.authorMahbubani, Krishnaa
dc.contributor.authorPark, Jong-Eun
dc.contributor.authorJimenez-Linan, Mercedes
dc.contributor.authorCampos, Lia
dc.contributor.authorKiselev, Vladimir Yu
dc.contributor.authorLindskog, Cecilia
dc.contributor.authorAyuk, Paul
dc.contributor.authorPrigmore, Elena
dc.contributor.authorStratton, Michael R
dc.contributor.authorSaeb-Parsy, Kourosh
dc.contributor.authorMoffett, Ashley
dc.contributor.authorMoore, Luiza
dc.contributor.authorBayraktar, Omer A
dc.contributor.authorTeichmann, Sarah
dc.contributor.authorTurco, Margherita Y
dc.contributor.authorVento-Tormo, Roser
dc.date.accessioned2021-12-24T14:37:06Z
dc.date.available2021-12-24T14:37:06Z
dc.date.issued2021-12
dc.date.submitted2021-02-13
dc.identifier.issn1061-4036
dc.identifier.others41588-021-00972-2
dc.identifier.other972
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331800
dc.description.abstractThe endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout the menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps of the human uterus and three-dimensional endometrial organoid cultures. We dissect the signaling pathways that determine cell fate of the epithelial lineages in the lumenal and glandular microenvironments. Our benchmark of the endometrial organoids reveals the pathways and cell states regulating differentiation of the secretory and ciliated lineages both in vivo and in vitro. In vitro downregulation of WNT or NOTCH pathways increases the differentiation efficiency along the secretory and ciliated lineages, respectively. We utilize our cellular maps to deconvolute bulk data from endometrial cancers and endometriotic lesions, illuminating the cell types dominating in each of these disorders. These mechanistic insights provide a platform for future development of treatments for common conditions including endometriosis and endometrial carcinoma.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/80
dc.subject/631/45
dc.subjectarticle
dc.titleMapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro.
dc.typeArticle
dc.date.updated2021-12-24T14:37:04Z
prism.endingPage1711
prism.issueIdentifier12
prism.publicationNameNat Genet
prism.startingPage1698
prism.volume53
dc.identifier.doi10.17863/CAM.79249
dcterms.dateAccepted2021-10-18
rioxxterms.versionofrecord10.1038/s41588-021-00972-2
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidRoberts, Kenny [0000-0001-6155-0821]
dc.contributor.orcidNikolakopoulou, Konstantina [0000-0003-2306-590X]
dc.contributor.orcidWoodhams, Benjamin [0000-0003-2801-5733]
dc.contributor.orcidArutyunyan, Anna [0000-0003-0453-5443]
dc.contributor.orcidPolanski, Krzysztof [0000-0002-2586-9576]
dc.contributor.orcidLi, Tong [0000-0002-8240-4476]
dc.contributor.orcidVaskivskyi, Vasyl [0000-0002-4080-4965]
dc.contributor.orcidMahbubani, Krishnaa [0000-0002-1327-2334]
dc.contributor.orcidStratton, Michael R [0000-0001-6035-153X]
dc.contributor.orcidSaeb-Parsy, Kourosh [0000-0002-0633-3696]
dc.contributor.orcidMoffett, Ashley [0000-0002-8388-9073]
dc.contributor.orcidMoore, Luiza [0000-0001-5315-516X]
dc.contributor.orcidBayraktar, Omer A [0000-0001-6055-277X]
dc.contributor.orcidTeichmann, Sarah [0000-0002-6294-6366]
dc.contributor.orcidVento-Tormo, Roser [0000-0002-9870-8474]
dc.identifier.eissn1546-1718
pubs.funder-project-idWellcome Trust (200841/Z/16/Z)
cam.issuedOnline2021-12-02


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