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dc.contributor.authorForder, Aisling
dc.contributor.authorHsing, Chi-Yun
dc.contributor.authorTrejo Vazquez, Jessica
dc.contributor.authorGarnis, Cathie
dc.date.accessioned2021-12-24T14:37:56Z
dc.date.available2021-12-24T14:37:56Z
dc.date.issued2021-12-06
dc.identifier.issn2073-4409
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331809
dc.description.abstractCommunication between cancer cells and the surrounding stromal cells of the tumor microenvironment (TME) plays a key role in promoting metastasis, which is the major cause of cancer death. Small membrane-bound particles called extracellular vesicles (EVs) are released from both cancer and stromal cells and have a key role in mediating this communication through transport of cargo such as various RNA species (mRNA, miRNA, lncRNA), proteins, and lipids. Tumor-secreted EVs have been observed to induce a pro-tumorigenic phenotype in non-malignant cells of the stroma, including fibroblasts, endothelial cells, and local immune cells. These cancer-associated cells then drive metastasis by mechanisms such as increasing the invasiveness of cancer cells, facilitating angiogenesis, and promoting the formation of the pre-metastatic niche. This review will cover the role of EV-mediated signaling in the TME during metastasis and highlight the therapeutic potential of targeting these pathways to develop biomarkers and novel treatment strategies.
dc.languageen
dc.publisherMDPI AG
dc.subjectextracellular vesicles
dc.subjectcancer
dc.subjectmetastasis
dc.subjecttumor microenvironment
dc.subjectcellular communication
dc.titleEmerging Role of Extracellular Vesicles and Cellular Communication in Metastasis.
dc.typeArticle
dc.date.updated2021-12-24T14:37:55Z
prism.issueIdentifier12
prism.publicationNameCells
prism.volume10
dc.identifier.doi10.17863/CAM.79258
dcterms.dateAccepted2021-11-26
rioxxterms.versionofrecord10.3390/cells10123429
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidTrejo Vazquez, Jessica [0000-0003-1308-4410]
dc.identifier.eissn2073-4409
cam.issuedOnline2021-12-06


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