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dc.contributor.authorZou, Geng
dc.contributor.authorMatuszewska, Marta
dc.contributor.authorJia, Ming
dc.contributor.authorZhou, Jianwei
dc.contributor.authorBa, Xiaoliang
dc.contributor.authorDuan, Juan
dc.contributor.authorZhang, Caishi
dc.contributor.authorZhao, Jian
dc.contributor.authorTao, Meng
dc.contributor.authorFan, Jingyan
dc.contributor.authorZhang, Xiangming
dc.contributor.authorJin, Wenping
dc.contributor.authorCui, Tianpen
dc.contributor.authorZeng, Xianyu
dc.contributor.authorJia, Min
dc.contributor.authorQian, Xiaojuan
dc.contributor.authorHuang, Chao
dc.contributor.authorZhuo, Wenxiao
dc.contributor.authorYao, Zhiming
dc.contributor.authorZhang, Lijun
dc.contributor.authorLi, Shaowen
dc.contributor.authorLi, Lu
dc.contributor.authorHuang, Qi
dc.contributor.authorWu, Bin
dc.contributor.authorChen, Huanchun
dc.contributor.authorTucker, Alexander W
dc.contributor.authorGrant, Andrew J
dc.contributor.authorHolmes, Mark A
dc.contributor.authorZhou, Rui
dc.date.accessioned2022-01-04T13:29:06Z
dc.date.available2022-01-04T13:29:06Z
dc.date.issued2022-02
dc.date.submitted2021-08-04
dc.identifier.issn2198-3844
dc.identifier.otheradvs3194
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331878
dc.description.abstractThere has been increasing concern that the overuse of antibiotics in livestock farming is contributing to the burden of antimicrobial resistance in people. Farmed animals in Europe and North America, particularly pigs, provide a reservoir for livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA ST398 lineage) found in people. This study is designed to investigate the contribution of MRSA from Chinese pig farms to human infection. A collection of 483 MRSA are isolated from 55 farms and 4 hospitals in central China, a high pig farming density area. CC9 MRSA accounts for 97.2% of all farm isolates, but is not present in hospital isolates. ST398 isolates are found on farms and hospitals, but none of them formed part of the "LA-MRSA ST398 lineage" present in Europe and North America. The hospital ST398 MRSA isolate form a clade that is clearly separate from the farm ST398 isolates. Despite the presence of high levels of MRSA found on Chinese pig farms, the authors find no evidence of them spilling over to the human population. Nevertheless, the ST398 MRSA obtained from hospitals appear to be part of a widely distributed lineage in China. The new animal-adapted ST398 lineage that has emerged in China is of concern.
dc.languageen
dc.publisherWiley
dc.subjectResearch Article
dc.subjectResearch Articles
dc.subjecthospitals
dc.subjectmethicillin‐resistant Staphylococcus aureus
dc.subjectpig farms
dc.subjectpopulation structures
dc.subjectST398
dc.titleA Survey of Chinese Pig Farms and Human Healthcare Isolates Reveals Separate Human and Animal Methicillin-Resistant Staphylococcus aureus Populations.
dc.typeArticle
dc.date.updated2022-01-04T13:29:05Z
prism.publicationNameAdv Sci (Weinh)
dc.identifier.doi10.17863/CAM.79328
dcterms.dateAccepted2021-10-13
rioxxterms.versionofrecord10.1002/advs.202103388
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidZhou, Rui [0000-0002-7903-9965]
dc.identifier.eissn2198-3844
pubs.funder-project-idMedical Research Council (MR/P007201/1)
pubs.funder-project-idMRC (via University of Birmingham) (19-0155 RRAK21517)
cam.issuedOnline2021-12-11


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