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dc.contributor.authorGoodwin, Amy
dc.contributor.authorJones, Emily JH
dc.contributor.authorSalomone, Simona
dc.contributor.authorMason, Luke
dc.contributor.authorHolman, Rebecca
dc.contributor.authorBegum-Ali, Jannath
dc.contributor.authorHunt, Anna
dc.contributor.authorRuddock, Martin
dc.contributor.authorVamvakas, George
dc.contributor.authorRobinson, Emily
dc.contributor.authorHolden, Catherine J
dc.contributor.authorTaylor, Chloë
dc.contributor.authorSmith, Tim J
dc.contributor.authorSonuga-Barke, Edmund
dc.contributor.authorBolton, Patrick
dc.contributor.authorCharman, Tony
dc.contributor.authorPickles, Andrew
dc.contributor.authorWass, Sam
dc.contributor.authorJohnson, Mark
dc.contributor.authorand the INTERSTAARS team
dc.date.accessioned2022-01-05T16:31:39Z
dc.date.available2022-01-05T16:31:39Z
dc.date.issued2021-12-20
dc.date.submitted2020-08-27
dc.identifier.issn2158-3188
dc.identifier.others41398-021-01698-9
dc.identifier.other1698
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332067
dc.descriptionFunder: MQ: Transforming Mental Health (MQ); doi: https://doi.org/10.13039/501100008162; Grant(s): MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83, MQ14PP83
dc.descriptionFunder: NIHR KCL/South London and Maudsley NHS Foundation Trust Biomedical Research Centre and Senior Investigator Award NF-SI-0617-10120
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) is first diagnosed during middle childhood, when patterns of difficulty are often established. Pre-emptive approaches that strengthen developing cognitive systems could offer an alternative to post-diagnostic interventions. This proof-of-concept randomised controlled trial (RCT) tested whether computerised gaze-based attention training is feasible and improves attention in infants liable to develop ADHD. Forty-three 9- to 16-month-old infants with a first-degree relative with ADHD were recruited (11/2015-11/2018) at two UK sites and randomised with minimisation by site and sex to receive 9 weekly sessions of either (a) gaze-contingent attention training (intervention; n = 20); or (b) infant-friendly passive viewing of videos (control, n = 23). Sessions were delivered at home with blinded outcome assessments. The primary outcome was a composite of attention measures jointly analysed via a multivariate ANCOVA with a combined effect size (ES) from coefficients at baseline, midpoint and endpoint (Registration: ISRCTN37683928 ). Uptake and compliance was good but intention-to-treat analysis showed no significant differences between 20 intervention and 23 control infants on primary (ES -0.4, 95% CI -0.9 to 0.2; Complier-Average-Causal Effect ES -0.6, 95% CI -1.6 to 0.5) or secondary outcomes (behavioural attention). There were no adverse effects on sleep but a small increase in post-intervention session fussiness. Although feasible, there was no support for short-term effects of gaze-based attention training on attention skills in early ADHD. Longer-term outcomes remain to be assessed. The study highlights challenges and opportunities for pre-emptive intervention approaches to the management of ADHD.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/477
dc.subject/692/699/476/1311
dc.subjectarticle
dc.titleINTERSTAARS: Attention training for infants with elevated likelihood of developing ADHD: A proof-of-concept randomised controlled trial.
dc.typeArticle
dc.date.updated2022-01-05T16:31:38Z
prism.issueIdentifier1
prism.publicationNameTransl Psychiatry
prism.volume11
dc.identifier.doi10.17863/CAM.79514
dcterms.dateAccepted2021-10-13
rioxxterms.versionofrecord10.1038/s41398-021-01698-9
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidGoodwin, Amy [0000-0003-2585-8452]
dc.contributor.orcidJones, Emily JH [0000-0001-5747-9540]
dc.contributor.orcidHunt, Anna [0000-0002-0864-4113]
dc.contributor.orcidCharman, Tony [0000-0003-1993-6549]
dc.contributor.orcidWass, Sam [0000-0002-7421-3493]
dc.contributor.orcidJohnson, Mark [0000-0003-4229-2585]
dc.identifier.eissn2158-3188
pubs.funder-project-idRCUK | Medical Research Council (MRC) (MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1, MR/K021389/1)
cam.issuedOnline2021-12-20


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