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Rho GTPases in Skeletal Muscle Development and Homeostasis.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Rodríguez-Fdez, Sonia  ORCID logo  https://orcid.org/0000-0001-5369-2969

Abstract

Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range of both cellular and physiological processes. In this review, we will summarize recent work on the role of Rho GTPase-regulated pathways in skeletal muscle development, regeneration, tissue mass homeostatic balance, and metabolism. In addition, we will present current evidence that links the dysregulation of these GTPases with diseases caused by skeletal muscle dysfunction. Overall, this information underscores the critical role of a number of members of the Rho GTPase subfamily in muscle development and the overall metabolic balance of mammalian species.

Description

Keywords

Cdc42, GTPase activating proteins, Rac1, RhoA, guanosine nucleotide exchange factors, metabolism, muscle mass, muscle regeneration, myogenesis, pak, rock, satellite cells, signaling, small G protein, Animals, Homeostasis, Humans, Muscle Development, Muscle, Skeletal, Muscular Diseases, Regeneration, rho GTP-Binding Proteins

Journal Title

Cells

Conference Name

Journal ISSN

2073-4409
2073-4409

Volume Title

10

Publisher

MDPI AG
Sponsorship
Junta de Castilla y León (CSI252P18, CSI145P20, CLC-2017-01)
Spanish Ministry of Science and Innovation (BES-2013-063573, RTI2018-096481-B-100, BES–2013–063573)
Programa de Apoyo a Planes Estratégicos de Investigación de Estructuras de Investigación de Excelencia of the Castilla-León autonomous government (CLC-2017-01)
CaixaBank (HR20-00164)
Fundación Ramón Areces (BEVP32P01S10090)
Asociación Española Contra el Cáncer (GC16173472GARC)