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dc.contributor.authorLussier, Tyler
dc.contributor.authorSchoebe, Natalie
dc.contributor.authorMai, Sabine
dc.date.accessioned2022-01-10T12:45:15Z
dc.date.available2022-01-10T12:45:15Z
dc.date.issued2021-12-31
dc.identifier.issn2073-4409
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332480
dc.description.abstractSmoldering multiple myeloma is a heterogeneous asymptomatic precursor to multiple myeloma. Since its identification in 1980, risk stratification models have been developed using two main stratification methods: clinical measurement-based and genetics-based. Clinical measurement models can be subdivided in three types: baseline measurements (performed at diagnosis), evolving measurements (performed over time during follow-up appointments), and imaging (for example, magnetic resonance imaging). Genetic approaches include gene expression profiling, DNA/RNA sequencing, and cytogenetics. It is important to accurately distinguish patients with indolent disease from those with aggressive disease, as clinical trials have shown that patients designated as "high-risk of progression" have improved outcomes when treated early. The risk stratification models, and clinical trials are discussed in this review.
dc.languageen
dc.publisherMDPI AG
dc.subjectsmoldering multiple myeloma
dc.subjectrisk stratification
dc.subjecttreatment
dc.titleRisk Stratification and Treatment in Smoldering Multiple Myeloma.
dc.typeArticle
dc.date.updated2022-01-10T12:45:14Z
prism.issueIdentifier1
prism.publicationNameCells
prism.volume11
dc.identifier.doi10.17863/CAM.79930
dcterms.dateAccepted2021-12-28
rioxxterms.versionofrecord10.3390/cells11010130
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSchoebe, Natalie [0000-0001-7417-3025]
dc.contributor.orcidMai, Sabine [0000-0002-5797-2201]
dc.identifier.eissn2073-4409
cam.issuedOnline2021-12-31


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