Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis.
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Authors
Akbari, Parsa
Watkins, Nicholas A
Pournaras, Dimitri J
Harris, Jessica
Timpson, Nicholas J
Publication Date
2022-08-18Journal Title
Platelets
ISSN
0953-7104
Publisher
Informa UK Limited
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Goudswaard, L. J., Corbin, L. J., Burley, K. L., Mumford, A., Akbari, P., Soranzo, N., Butterworth, A. S., et al. (2022). Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis.. Platelets https://doi.org/10.1080/09537104.2021.2003317
Abstract
Higher body mass index (BMI) is a risk factor for thrombosis. Platelets are essential for hemostasis but contribute to thrombosis when activated pathologically. We hypothesized that higher BMI leads to changes in platelet characteristics, thereby increasing thrombotic risk. The effect of BMI on platelet traits (measured by Sysmex) was explored in 33 388 UK blood donors (INTERVAL study). Linear regression showed that higher BMI was positively associated with greater plateletcrit (PCT), platelet count (PLT), immature platelet count (IPC), and side fluorescence (SFL, a measure of mRNA content used to derive IPC). Mendelian randomization (MR), applied to estimate a causal effect with BMI proxied by a genetic risk score, provided causal estimates for a positive effect of BMI on both SFL and IPC, but there was little evidence for a causal effect of BMI on PCT or PLT. Follow-up analyses explored the functional relevance of platelet characteristics in a pre-operative cardiac cohort (COPTIC). Linear regression provided observational evidence for a positive association between IPC and agonist-induced whole blood platelet aggregation. Results indicate that higher BMI raises the number of immature platelets, which is associated with greater whole blood platelet aggregation in a cardiac cohort. Higher IPC could therefore contribute to obesity-related thrombosis.
Sponsorship
Medical Research Council (MR/L003120/1)
British Heart Foundation (None)
British Heart Foundation (RG/18/13/33946)
Identifiers
External DOI: https://doi.org/10.1080/09537104.2021.2003317
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332820
Rights
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/
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