Research data supporting Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence
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Authors
Alsio, B
Phillips, BU
Sala-Bayo, Julia
Nilsson, SRO
Calafat-Pla, TC
Rizwand, A
Plumbridge, JM
Lopez-Cruz, L
Dalley, JW
Cardinal, RN
Mar, AC
Robbins, TW
Publication Date
2022-01-26Type
Dataset
Metadata
Show full item recordCitation
Alsio, B., Phillips, B., Sala-Bayo, J., Nilsson, S., Calafat-Pla, T., Rizwand, A., Plumbridge, J., et al. (2022). Research data supporting Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence [Dataset]. https://doi.org/10.17863/CAM.80290
Description
We tested the hypotheses that D2R agonism impairs reversal learning by blocking negative feedback and that antagonism of D1-like receptors (D1R) impairs learning from positive feedback. Male Lister Hooded rats were trained on a novel visual reversal learning task. Performance on “probe trials”, during which the correct or incorrect stimulus was presented with a third, probabilistically rewarded (50% of trials) and therefore intermediate stimulus, revealed individual learning curves for the processes of positive and negative feedback. The effects of D2R and D1R agonists and antagonists were evaluated. A separate cohort was tested on a spatial probabilistic reversal learning (PRL) task after D2R agonism.
There are eight .csv files in this folder, corresponding to the following experiments:
(refer to Table 1 in the manuscript)
Alsio_2019_quinpirole_PRL.csv -- Cohort VI probabilistic reversal learning
Alsio_2019_quinpirole_VPVD_groups.csv -- Cohort II+III quinpirole experiment
Alsio_2019_quinpirole_VPVD_trials.csv -- Cohort II+III quinpirole experiment
Alsio_2019_Raclo_SCH39166_TSVR_trials.csv -- Cohort IV (TSVR experiment)
Alsio_2019_Raclopride_SCH39166_VPVD_groups.csv Cohort IV+V (VPVD experiment)
Alsio_2019_raclopride_SCH39166_VPVD_trials.csv Cohort IV+V (VPVD experiment)
Alsio_2019_SKF81297_VPVD_groups.csv -- Cohort II+III SKF81297 experiment
Alsio_2019_SKF81297_VPVD_trials.csv -- Cohort II+III SKF81297 experiment
Format
NA
Keywords
dopamine, rats, cognition, reinforcement learning
Relationships
Sponsorship
This research was funded by a Wellcome Trust Senior Investigator award to TWR (104631/Z/14/Z). All experiments were conducted at the Behavioural and Clinical Neuroscience Institute, which was jointly funded by the Medical Research Council (MRC) and the Wellcome Trust. This research was also supported in part by the UK National Health Service (NHS) National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre; the views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. An MRC Clinical Research Infrastructure award supported part of this work. J.S.B. was supported by a PhD scholarship from the La Caixa Foundation, Spain, and a studentship from Boehringer Ingelheim Pharma GmbH, Germany.
Funder references
Wellcome Trust (104631/Z/14/Z)
Identifiers
This record's DOI: https://doi.org/10.17863/CAM.80290
Rights
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/
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