A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
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Authors
Velasco-Aviles, Sergio
Casillas-Bajo, Angeles
Frutos-Rincón, Laura
Velasco-Serna, Enrique
Gallar, Juana
Publication Date
2022-01-25Journal Title
Elife
ISSN
2050-084X
Publisher
eLife Sciences Publications, Ltd
Type
Article
This Version
VoR
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Velasco-Aviles, S., Patel, N., Casillas-Bajo, A., Frutos-Rincón, L., Velasco-Serna, E., Gallar, J., Arthur-Farraj, P., et al. (2022). A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.. Elife https://doi.org/10.7554/eLife.72917
Abstract
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated genetic compensatory mechanism within this family of proteins, blocks negative regulators of myelination ensuring peripheral nerve developmental myelination and remyelination after injury. Thus, when Hdac4 and 5 are knocked-out from Schwann cells in mice, a JUN-dependent mechanism induces the compensatory overexpression of Hdac7 permitting, although with a delay, the formation of the myelin sheath. When Hdac4,5 and 7 are simultaneously removed, the Myocyte-specific enhancer-factor d (MEF2D) binds to the promoter and induces the de novo expression of Hdac9, and although several melanocytic lineage genes are misexpressed and Remak bundle structure is disrupted, myelination proceeds after a long delay. Thus, our data unveil a finely tuned compensatory mechanism within the class IIa Hdac family, coordinated by distinct transcription factors, that guarantees the ability of Schwann cells to myelinate during development and remyelinate after nerve injury.
Sponsorship
Wellcome Trust (UNS38871)
Identifiers
External DOI: https://doi.org/10.7554/eLife.72917
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332952
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