Activity-induced instabilities of brain organoids.
Published version
Peer-reviewed
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Type
Article
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Authors
Thijssen, Kristian https://orcid.org/0000-0001-9636-8624
Kusters, Guido LA https://orcid.org/0000-0002-6004-9768
Doostmohammadi, Amin https://orcid.org/0000-0002-1116-4268
Abstract
We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
Description
Funder: http://dx.doi.org/10.13039/501100007601; doi: Horizon 2020; Grant(s): 722497
Funder: Dutch Research Council (NWO) in the framework of the ENW PPP Fund for the top sectors and from the Ministry of Economic Affairs in the framework of the ‘PPS-Toeslagregeling’.
Keywords
Brain, Induced Pluripotent Stem Cells, Organoids
Journal Title
Eur Phys J E Soft Matter
Conference Name
Journal ISSN
1292-8941
1292-895X
1292-895X
Volume Title
44
Publisher
Springer Science and Business Media LLC
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Sponsorship
EPSRC (EP/T031247/1)